Artículos en revistas:
A New Device Based on Interferometric Optical Detection Method for Label-Free Screening of C-Reactive Protein
A New Device Based on Interferometric Optical Detection Method for Label-Free Screening of C-Reactive Protein
Año:2018
Áreas de investigación
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Biosensores
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Descripción
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| In previous work, the performance of a compact and cost-effective point-of-care (PoC) device based on the increase relative optical power (IROP) methodology is reported and it is determined the enhancement in comparison with standard high-resolution spectrometry in terms of limit of detection. This paper describes a new label-free IROP-based biomedical device capable of working with low concentration of reagents and low sample volume per measurement in order to be used for screening different steps necessary in immunoassay optimization. This new approach significantly improves the sensing performance in terms of read-out signal (?IROP) per nanometer of biofilm in comparison with our previous work. This improvement is achieved due to the implementation of a laser as light source of the optical read-out system and the redesign of Fabry?Perot transducers by optimizing their reflectivity response and reducing their sensing area. For demonstrating the screening capability of this new PoC device in several immunoassays steps and methodologies, a C-reactive protein detection assay was carried out as a potential application and assay model. It is remarkable that only 10 ?L of sample was used per measurement. This labelfree IROP-based device complies an easy-to-use and cost-effective tool for immunoassays optimization in terms of performance, reagents cost, and measuring time. | |
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Internacional
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JCR del ISI
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Título de la revista
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IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT |
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ISSN
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1557-9662 |
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Factor de impacto JCR
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Información de impacto
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Volumen
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DOI
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10.1109/TIM.2018.2876073 |
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Número de revista
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1 |
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Hasta la página
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7 |
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Participantes
- Autor: Mª Victoria Maigler López (UPM)
- Autor: Rocio Lopez Espinosa (UPM)
- Autor: Alvaro Lavin Hueros (UPM)
- Autor: Miguel Holgado Bolaños (UPM)
- Autor: Maria Fe Laguna Heras (UPM)
- Autor: Francisco Javier Sanza (BIOD SL)
- Autor: Beatriz Santamaria Fernandez (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
- Creador: Grupo de Investigación: Grupo de Óptica Fótonica y Biofotónica (GOFB)
- Centro o Instituto I+D+i: Centro Laser
- Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
- Departamento: Física Aplicada e Ingeniería de Materiales
S2i 2023 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)