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Abstract
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| Transgenic mouse for the Monocarboxylate Transporter 1 (MCT1) gene (SLC16A1) with one invalidated allele presented resistance to diet-induced obesity. In humans a single-nucleotide polymorphism (SNP), T1470A (rs1049434), for this gene has been related with an impaired lactate transport in T male carriers. Therefore, this SNP could have an influence in body composition changes, simulating the results seen in transgenic mice. PURPOSE: To investigate the influence of the T1470A SNP of the MCT1 gene on percentage fat (%fat) changes after a 6-month weight loss program in obese and overweight healthy people. METHODS: 91 women (39.1±8.3 years, 80.7±10.5 kg) and 84 men (39.6±8.2 years, 96± 10.7 kg) followed a 24-week weight loss intervention including a controlled training program (supervised exercise group, S: 3 times/week, 38-60 min/session; strength, endurance and combined training; N=134) or exercise recommendations (non-supervised exercise group, NS; N=39). All groups had caloric restriction of 25-30% of their energy expenditure. Genotyping was done using PCR and direct sequencing or Real Time PCR. Three-way (genotype x exercise group x sex) ANCOVA was conducted for compare the final values of %fat, adjusting by the initial values. Effects sizes (ES) and their 90% confidence intervals (CI) were calculated to show the magnitude of the effect (standardized differences in means: Cohen?s units) of carrying the A allele. RESULTS: A genotype x exercise group x sex interaction was observed (p=0.017). TT women had less final %fat in the whole group (p=0.025, 1.94%) as well as within the NS group (p=0.002, 4.49%) than A carriers. The ES associated indicate that the A allele has a moderate (ES=1.15, CI=1.88, 0.42) and very likely positive effect only in women within the NS group. For men the A carriers ended with less %fat than TT subjects (p=0.037, 1.87%), with small and possibly negative ES in the S group (ES=-0.25, CI=-0.02, 0.52) and small and likely negative in NS (ES=-0.46, CI=0.01, 0.91). CONCLUSIONS: The T1470A SNP might have an influence on %fat changes after a weight loss program. The effect seems to be different depending on sex and type of exercise intervention. Further studies are necessary to confirm this association and to clarify the underlying mechanisms. Supported by Spanish Government Grant DEP2008-06354-C04-01. | |
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International
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JCR
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Title
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Medicine And Science in Sports And Exercise |
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ISBN
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0195-9131 |
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Impact factor JCR
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4,291 |
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Impact info
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Volume
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50 |
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10.1249/01.mss.0000536608.11552.6f |
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Journal number
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5S |
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From page
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465 |
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To page
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465 |
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Month
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SIN MES |
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Ranking
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