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Memorias de investigación
Ponencias en congresos:
Assessment of geometry in 2D immune systems using high accuracy laser-based bioprinting techniques
Año:2018
Áreas de investigación
  • Biomedicina,
  • Ingeniería mecánica, aeronaútica y naval,
  • Ingenieria mecanica
Datos
Descripción
The immune system is a very complex system that comprises a network of genetic and signaling pathways subtending a network of interacting cells. The location of the cells in a network, along with the gene products they interact with, rules the behavior of the immune system. Therefore, there is a great interest in understanding properly the role of a cell in such networks to increase our knowledge of the immune system response. In order to acquire a better understanding of these processes, cell printing with high spatial resolution emerges as one of the promising approaches to organize cells in two and three-dimensional patterns to enable the study the geometry influence in these interactions. In particular, laser assisted bio-printing techniques using sub-nanosecond laser sources have better characteristics for application in this field, mainly due to its higher spatial resolution, cell viability percentage and process automation. This work presents laser assisted bio-printing of antigen-presenting cells (APCs) in two-dimensional geometries, placing cellular components on a matrix previously generated on demand, permitting to test the molecular interactions between APCs and lymphocytes; as well as the generation of two-dimensional structures designed ad hoc in order to study the mechanisms of mobilization of immune system cells. The use of laser assisted bio-printing, along with APCs and lymphocytes emulate the structure of different niches of the immune system so that we can analyse functional requirement of these interaction.
Internacional
Si
Nombre congreso
Photonics West 2018
Tipo de participación
960
Lugar del congreso
San Francisco (EE.UU.)
Revisores
Si
ISBN o ISSN
9781510615250
DOI
10.1117/12.2253622
Fecha inicio congreso
30/01/2018
Fecha fin congreso
01/02/2018
Desde la página
1
Hasta la página
1
Título de las actas
Proc. SPIE 10062, Optical Interactions with Tissue and Cells XXVIII
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Sara Lauzurica Santiago (UPM)
  • Autor: Andrés Márquez Fernández (UPM)
  • Autor: Carlos Luis Molpeceres Alvarez (UPM)
  • Autor: L Notario (Instituto de Salud Carlos III)
  • Autor: Miguel Gómez Fontela (UPM)
  • Autor: P Lauzurica (Instituto de Salud Carlos III)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Manufactura Avanzada con Láser
  • Centro o Instituto I+D+i: Centro Laser
  • Departamento: Física Aplicada e Ingeniería de Materiales
S2i 2021 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
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