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Descripción
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| The immune system is a very complex system that comprises a network of genetic and signaling pathways subtending a network of interacting cells. The location of the cells in a network, along with the gene products they interact with, rules the behavior of the immune system. Therefore, there is a great interest in understanding properly the role of a cell in such networks to increase our knowledge of the immune system response. In order to acquire a better understanding of these processes, cell printing with high spatial resolution emerges as one of the promising approaches to organize cells in two and three-dimensional patterns to enable the study the geometry influence in these interactions. In particular, laser assisted bio-printing techniques using sub-nanosecond laser sources have better characteristics for application in this field, mainly due to its higher spatial resolution, cell viability percentage and process automation. This work presents laser assisted bio-printing of antigen-presenting cells (APCs) in two-dimensional geometries, placing cellular components on a matrix previously generated on demand, permitting to test the molecular interactions between APCs and lymphocytes; as well as the generation of two-dimensional structures designed ad hoc in order to study the mechanisms of mobilization of immune system cells. The use of laser assisted bio-printing, along with APCs and lymphocytes emulate the structure of different niches of the immune system so that we can analyse functional requirement of these interaction. | |
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Internacional
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Si |
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Nombre congreso
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Photonics West 2018 |
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Tipo de participación
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960 |
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Lugar del congreso
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San Francisco (EE.UU.) |
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Revisores
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Si |
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ISBN o ISSN
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9781510615250 |
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DOI
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10.1117/12.2253622 |
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Fecha inicio congreso
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30/01/2018 |
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Fecha fin congreso
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01/02/2018 |
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Desde la página
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1 |
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Hasta la página
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1 |
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Título de las actas
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Proc. SPIE 10062, Optical Interactions with Tissue and Cells XXVIII |