Observatorio de I+D+i UPM

Memorias de investigación
Ponencias en congresos:
LIFT bioprinting for the study of the immune response
Áreas de investigación
  • Biomedicina,
  • Ingeniería mecánica, aeronaútica y naval,
  • Ingenieria mecanica
Immunology is a transversal field that is governed by a complex network of genetic and signalling pathways subtending a network of interacting cells. Laser bioprinting is a powerful tool to study complex biological systems like the ones that govern the immune response. The high accuracy and non-destructive nature of LIFT (Laser Induced Forward Transfer) is applied to the study of cell-cell interaction. In particular, single cell laser bioprinting helps to understand the relationship between the cell and their local environment. In this context, mobility of the cells in a network, along with their situation and the gene products they interact with, plays an important role in the behaviour of the immune system. In this work, we use a laser induced forward transfer blister assisted (BALIFT) approach to assess these cell-cell interactions in vitro. This method helps to understand properly the role of a cell within a network to increase our knowledge of the immune system response. This work presents BALIFT bioprinting of single hematopoietic cells with high spatial resolution. In particular, NK cells (natural killer) and T-lymphocyte are printed in different laser conditions and specific patterns to study cell viability and cell-cell interaction. By means of this technique, we can place cellular components on a previously designed matrix, allow us to test the molecular interactions between lymphocytes and pathogens.
Nombre congreso
Bioprinting & 3D-Printing in the Life Sciences EU 2018
Tipo de participación
Lugar del congreso
Rotterdam, Países Bajos
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Título de las actas
Esta actividad pertenece a memorias de investigación
  • Autor: Sara Lauzurica Santiago (UPM)
  • Autor: Andrés Márquez Fernández (UPM)
  • Autor: Carlos Luis Molpeceres Alvarez (UPM)
  • Autor: Miguel Gómez Fontela (UPM)
  • Autor: P Lauzurica (Instituto de Salud Carlos III)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Manufactura Avanzada con Láser
  • Centro o Instituto I+D+i: Centro Laser
S2i 2021 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)