Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
A directional-linear Bayesian network and its application for clustering and simulation of neural somas
Año:2019
Áreas de investigación
  • Inteligencia artificial
Datos
Descripción
Neural somas perform most of the metabolic activities in the neuron and support the chemical process that generates the basic elements of the synapses, and consequently, of the brain activity. The morphology of the somas is one of the fundamental features for classifying neurons and their functionality. In this study, we characterize the morphology of 39 three-dimensional reconstructed human pyramidal somas in terms of their multiresolutional Reeb graph representation, from which we extract a set of directional and linear variables to perform model-based clustering. To deal with this dataset, we introduce the novel Extended Mardia-Sutton mixture model whose mixture components are distributed according to a newly proposed multivariate probability density function that is able to capture the directionallinear correlations. We exploit the capabilities of Bayesian networks in combination with the Structural Expectation-Maximization algorithm to learn the finite mixture model that clusters the neural somas by their morphology and the conditional independence constraints between variables. We also derive the Kullback-Leibler divergence of the Extended Mardia-Sutton distribution to be used as a measure of similarity between soma clusters. The proposed finite mixture model discovered three subtypes of human pyramidal somas. We performed Weltch t-tests and Watson-Williams tests, as well as rule-based identification of clusters to characterize each group by its most prominent features. Furthermore, the resulting model allowed us to simulate 3D virtual representations of somas from each cluster, which can be a useful tool for neuroscientists to reason and suggest new hypotheses.
Internacional
Si
JCR del ISI
Si
Título de la revista
Ieee Access
ISSN
2169-3536
Factor de impacto JCR
3,557
Información de impacto
Datos JCR del año 2017
Volumen
In Press
DOI
10.1109/ACCESS.2019.2918494
Número de revista
Desde la página
0
Hasta la página
0
Mes
JUNIO
Ranking
Q1: 24 de 148
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Sergio Luengo Sanchez (UPM)
  • Autor: Pedro Maria Larrañaga Mugica (UPM)
  • Autor: Maria Concepcion Bielza Lozoya (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Inteligencia Artificial
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