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Descripción
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| Background : Within the study of alimentary allergy, previous reports have shown different aspects of the micro and macromolecular changes that happen in the mucosa associated lymphoid tissue (MALT). Even with the wide knowledge regarding the sensitization process, there are still several events that remain unclear, making it impossible to achieve definitive treatments against the disease yet. For that reason, we propose to deepen in these studies by analyzing the effects of Pru p 3 (major allergen of peach) sensitization in different MALT systems. Method : Both in vitro and in vivo approaches were developed for our studies, employing Pru p 3 and its lipid ligand as a model for food allergy sensitization. For the first case, a wide variety of cell lines from different tissue origin were used and multiple parameters, including allergen transportation and cytokines production and release, were studied. For the in vivo analysis, mice were sensitized using different routes and several cellular and histological events were studied. Results : Pru p 3 administration in epithelial cell lines from skin, gut and lung showed differential transportation of the allergen, together with a differential pattern in the cytokines expression. Similarly, the in vivo studies showed differential tissue remodeling and lymphocyte infiltration, depending on which route was used for Pru p 3 sensitization (nasal, gastrointestinal or epicutaneous). Conclusion : Allergy is a systemic disease in which very different factors take part, from external barriers to cellular signaling all over the body. These results provide new insights in our understanding of the MALT. Although previous studies already reported changes occurring in this tissue in in vivo models of peach allergy, this is the first report comparing different routes and analyzing them simultaneously, allowing us to understand sensitization effects happening both near the sensitization pathway and through other tissues and systems away from it. | |
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Internacional
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Si |
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Nombre congreso
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EAACI |
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Tipo de participación
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970 |
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Lugar del congreso
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Lisboa |
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Revisores
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Si |
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ISBN o ISSN
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1398-9995 |
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DOI
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Fecha inicio congreso
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01/06/2019 |
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Fecha fin congreso
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05/06/2019 |
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Desde la página
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1 |
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Hasta la página
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965 |
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Título de las actas
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Special Issue:Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 01?05 June 2019, Lisbon, Portugal |