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Memorias de investigación
Ponencias en congresos:
Association between sensitization to grasses and molds as cause of exacerbation asthma in autumn
Año:2019
Áreas de investigación
  • Salud,
  • Mecanismos moleculares de enfermedad,
  • Bioquímica
Datos
Descripción
Background : Mold airborne and grass pollen are important aeroallergen sources with different seasonal behaviour: whereas pollen levels have a marked seasonality (high levels in late spring and early summer), fungal spores are an ever component of the environment, reaching highest levels in late spring and early autumn. In Central Spain, clinical evidences about patients with grass pollen allergy who suffer from asthma attacks in September- October have been reported, when pollen is not longer present but grass straw is. Method : In the current study, several assays have been performed in order to prove a possible co- sensitization phenomenon between grasses and associated- fungi. After identifying fungal species present in grass straw harvested in autumn, IgE immunodetection assays were performed to detect sensitization to both grass straw proteins and associated- mold proteins in a group of grass pollen sensitized- patients. Results : After having identified five fungal isolates from grasses which have long been associated with allergy, immunodetection assay revealed that a high percentage of grass pollen sensitizedpatients have sIgE against fungal proteins, having these patients IgE against grass straw proteins too. Moreover, results suggest that allergens present in pollen could be conserved in grass straw. Conclusion : With the present study, we observed that grasses harvested in September- October could be infected with mold spores from species that play an important role in respiratory allergy. Patients with grass pollen sensitization showed a positive recognition to mold and grass straw proteins. But also, allergic grass pollen proteins interact with fungal spores, acting spores like vehicle of transmission of straw allergens. In summary, co- sensitization process between both aeroallergen sources could be happening, being the base of asthma attacks observed in autumn.
Internacional
Si
Nombre congreso
EAACI
Tipo de participación
970
Lugar del congreso
Lisboa
Revisores
Si
ISBN o ISSN
1398-9995
DOI
Fecha inicio congreso
01/06/2019
Fecha fin congreso
05/06/2019
Desde la página
1
Hasta la página
965
Título de las actas
Special Issue:Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 01?05 June 2019, Lisbon, Portugal
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Guadalupe Hernandez Ramirez (UPM)
  • Autor: Diego Pazos Castro (UPM)
  • Autor: Maria Garrido Arandia (UPM)
  • Autor: Jaime Maria Tome Amat (UPM)
  • Autor: Luis Fernandez Pacios (UPM)
  • Autor: Araceli Diaz Perales (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Departamento: Biotecnología - Biología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
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