Memorias de investigación
Artículos en revistas:
Discriminating Alzheimer's disease progression using a new hippocampal marker from T1-weighted MRI: The local surface roughness
Año:2019
Áreas de investigación
  • Ingenierías,
  • Automática
Datos
Descripción
Hippocampal atrophy is one of the main hallmarks of Alzheimer's disease (AD). However, there is still controversy about whether this sign is a robust finding during the early stages of the disease, such as in mild cognitive impairment (MCI) and subjective cognitive decline (SCD). Considering this background, we proposed a new marker for assessing hippocampal atrophy: the local surface roughness (LSR). We tested this marker in a sample of 307 subjects (normal control (NC) = 70, SCD = 87, MCI = 137, AD = 13). In addition, 97 patients with MCI were followed-up over a 3-year period and classified as stable MCI (sMCI) (n = 61) or progressive MCI (pMCI) (n = 36). We did not find significant differences using traditional markers, such as normalized hippocampal volumes (NHV), between the NC and SCD groups or between the sMCI and pMCI groups. However, with LSR we found significant differences between the sMCI and pMCI groups and a better ability to discriminate between NC and SCD. The classification accuracy of the LSR for NC and SCD was 68.2%, while NHV had a 57.2% accuracy. In addition, the classification accuracy of the LSR for sMCI and pMCI was 74.3%, and NHV had a 68.3% accuracy. Cox proportional hazards models adjusted for age, sex, and education were used to estimate the relative hazard of progression from MCI to AD based on hippocampal markers and conversion times. The LSR marker showed better prediction of conversion to AD than NHV. These results suggest the relevance of considering the LSR as a new hipocampal marker for the AD continuum.
Internacional
Si
JCR del ISI
Si
Título de la revista
Human Brain Mapping
ISSN
1065-9471
Factor de impacto JCR
4,927
Información de impacto
Datos JCR del año 2017
Volumen
40
DOI
10.1002/hbm.24478
Número de revista
5
Desde la página
1666
Hasta la página
1676
Mes
ABRIL
Ranking
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Participantes
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Departamento: Ingeniería Eléctrica, Electrónica Automática y Física Aplicada