Observatorio de I+D+i UPM

Memorias de investigación
Proyecto de I+D+i:
RememberEx: Human Subcortical-Cortical Circuit Dynamics for Remembering the Exceptional
Año:2019
Áreas de investigación
Datos
Descripción

Our memory system is optimised for remembering the exceptional over the mundane. We remember better those events that violate predictions generated by the prevailing context, particularly because of surprise or emotional impact. Understanding how we form and retrieve long-term memories for important or salient events is critical for combating the rapidly growing incidence of pathologies associated with memory dysfunction with huge socio-econonomic burden. Human lesion and non-invasive functional imaging data, motivated by findings from animal models, have identified subcortical structures that are critical for upregulating hippocampal function during salient event memory. However, mechanistic understanding of these processes in humans remains scarce, and requires better experimental approaches such as direct intracranial recordings from, and focal electrical stimulation of, these subcortical structures.
This project will characterise human subcortico-cortical neuronal circuit dynamics associated with enhanced episodic memory for salient stimuli by studying direct recordings from human hippocampus, amygdala, nucleus accumbens, ventral midbrain and cortex. Within this framework, I will elucidate the electrophysiological mechanisms underlying amygdala-hippocampal-cortical coupling that lead to better memory for emotional stimuli, extend the hippocampal role in detecting unpredicted stimuli to define its role in orchestrating cortical dynamics in unpredictable contexts, and discover the neuronal response profile of the human mesolimbic dopamine system during salient stimulus encoding. The predicted results, based on my own preliminary data, will offer several conceptual breakthroughs, particularly regarding hippocampal function and the role of dopaminergic ventral midbrain in memory. The knowledge gained from this project is a fundamental requirement for designing therapeutic interventions for patients with memory deficits and other neuropsychiatric disorders.

Internacional
Si
Tipo de proyecto
Proyectos y convenios en convocatorias públicas competitivas
Entidad financiadora
Nacionalidad Entidad
Sin nacionalidad
Tamaño de la entidad
Fecha concesión
23/04/2019
Esta actividad pertenece a memorias de investigación
Participantes
  • Director: Bryan Strange (UPM)
  • Participante: Manuela Costa (UPM)
  • Participante: Alba Peris Yagüe (UPM)
  • Participante: Svenja Treu (UPM)
  • Participante: Marta Maria Casales Santa (UPM)
  • Participante: Darya Rivka Frank . (UPM)
  • Participante: Diego Lozano Soldevilla (UPM)
  • Participante: Maria Alejandra Korovaichuk . (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: No seleccionado
  • Grupo de Investigación: Tecnologías para Ciencias de la Salud
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2023 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)