Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Pru p 3-Glycodendropeptides Based on Mannoses PromoteChanges in the Immunological Properties of Dendriticand T-Cells from LTP-Allergic Patients
Año:2019
Áreas de investigación
  • Biomedicina,
  • Biología molecular, celular y genética
Datos
Descripción
Scope: Glycodendropeptides (GDPs) functionalized with mannosecan enhance allergen interaction with dendritic cells (DCs) via C-type lectinreceptors (CLRs), modulating the immune response. They can present multiplepeptides and have potential applications for diagnosis and treatment offood allergy (FA). The immune response induced by GDPs with mannose andPru p 3 peptides (mono/tetravalent) with ester (D1ManPrup3/D4ManPrup3)or ether linkers (D1Man-O-Prup3/D4Man-O-Prup3) in lipid-transfer-protein-allergic patients and tolerant controls is analyzed.Methods and results: The immunological response induced by GDPs isstudied by assessing monocyte-derived-DC maturation, lymphocyteproliferation, cytokine production, and basophil response by flow cytometry.DnManPrup3 was recognized by DCs via CLRs inducing DC maturation in allsubjects. However, CCR7 expression is significantly upregulated in allergicpatients compared to tolerant controls. These changes correlate withlymphocyte proliferation and specific production of Th2/Th1 cytokines inallergic patients. Moreover, D1ManPrup3 does not induce basophil activation.Conclusion: DnManPrup3 induces changes in DC maturation and lymphocyteproliferation, indicating specific recognition via CLRs. Prup3-GDPs arerecognized by immune cells, inducing a specific immune response andmodulating the immunological response in FA patients. The specific geometryof D1ManPrup3 in particular makes it a potential candidate for specificimmunotherapy development.
Internacional
Si
JCR del ISI
Si
Título de la revista
Molecular Nutrition & Food Research
ISSN
1613-4125
Factor de impacto JCR
5,309
Información de impacto
Volumen
63
DOI
10.1002/mnfr.201900553
Número de revista
Desde la página
0
Hasta la página
11
Mes
OCTUBRE
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Francisca Palomares (IBIMA-Regional University Hospital of Malaga-UMA)
  • Autor: Javier Ramos-Soriano (Institute for Chemical Research (IIQ)CSIC ¿ University of Seville)
  • Autor: Francisca Gómez (Allergy Unit/IBIMA-Regional University Hospital of Malaga-UMA)
  • Autor: Ainhoa Mascaraque (Institute for Chemical Research (IIQ)CSIC ¿ University of Seville)
  • Autor: Gador Bogas (IBIMA-Regional University Hospital of Malaga-UMA)
  • Autor: James Richard Perkins (IBIMA-Regional University Hospital of Malaga-UMA)
  • Autor: Miguel Gonzalez (IBIMA-Regional University Hospital of Malaga-UMA)
  • Autor: Maria Jose Torres (IBIMA-Regional University Hospital of Malaga-UMA)
  • Autor: Araceli Diaz Perales (UPM)
  • Autor: Javier Rojo (Institute for Chemical Research (IIQ) CSIC - University of Seville)
  • Autor: Cristobalina Mayorga (IBIMA-Regional University Hospital of Malaga-UMA)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Departamento: Biotecnología - Biología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
S2i 2021 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
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