Observatorio de I+D+i UPM

Descripción
In this work we propose an image registration algorithm to automatically fit protein atomic domain models into medium-resolution three-dimensional electron microscopy reconstructions (3D-EM map). The approach employs a flexible registration algorithm whose optimizer controls the generation of stereo-chemically correct models from a given reference domain belonging to a super-family of proteins. The proposed algorithm generates models automatically in the correct direction until the optimizer converges to the best fitted model. A local gradient optimizer is employed for this task. Mutual Information is used as an alternative to Cross Correlation Coefficient. An additional rigid registration that uses a local gradient optimization is applied between each generated model and the 3D-EM map.
Internacional	Si
Nombre congreso	5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008)
Tipo de participación	960
Lugar del congreso	Paris
Revisores	Si
ISBN o ISSN	978-1-4244-2003-2
DOI
Fecha inicio congreso	14/05/2008
Fecha fin congreso	17/05/2008
Desde la página	983
Hasta la página	986
Título de las actas	Proceedings of 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro.

Esta actividad pertenece a memorias de investigación

• Participante: Carlos O.S. Sorzano (CSIC, Madrid)
• Participante: Jose Mª Carazo (CSIC, Madrid)
• Autor: Andres de Santos Lleo (UPM)
• Participante: Laura Fernandez de Manuel (UPM)
• Autor: Maria Jesus Ledesma Carbayo (UPM)
• Participante: J. Atineza Herrero (CSIC, Madrid)

• Creador: Grupo de Investigación: Tecnología de imágenes biomédicas
• Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
• Departamento: Ingeniería Electrónica