|We present a potential high sensitive label-free optical bio-sensing systcm based on biophotonic sensing cells, which can be fabricated and interrogated al wafer or di rosablc chip levcl. The key bencfits rely on the holistic approach thal combincs bio-photonic resonanl micro-nano cavitics and advanccd sub-micron spot sizc oplical inlcrrogalion tcchnologics. The propos d optical sensing sy'tem wi 11 bc trcmcndoLlsly scnsitivc to rcfraclivc indcx variations by Illcans of thc observation of Ihe reflcelivity profilc of Ihrec complemcntary cnhanced sub-micron spot sizc opli al technologies simultaneously (Reflectometry, Spectrometry and Ellipsomelry based lechniques), and the magnificalion due to Ihc biophotonics resonant sen. ing eells, making possiblc lo determine with more reliability and sensitivily Ihe biomolc ular interaction with the rcceptor biomolceules. This novcl scnsing syslcm also offcrs an incxpensive sollltion for inlegralion and packaging because it overcomes the need for lIsing complex systems for light eoupling such as inverted tarers or grating couplers usually used in planar micro-nano pholonic devices, because the sen or evaluation is done measuring vertically colleeting Ihe reflected light of the bio-photonic resonant sensing cells. The scnsing syslem may use a tightly focused beam which allows Illeasuring in situ mieran/sub-micron size gcometries, Illaking thc routine scrccning more co I-cffectivc and suilablc to pcrfonn hundrcds of Illcasuremenls on a single or several samplcs for Illulli-ingle or multiparameter measurcments. The simultaneous u 'cd of the three differcnt optical techniqucs will allow Ihc syslems to achievc a high throughput and productivity in comparison with olher established analytical techniqlles. Thc levels 01" sensilivity expected are in thc order of 10'(,/10-7 refraetive index units (RIU).
|PHOTONICS WEST 2009. SPIE
|E.E.U.U. DE AMERICA
|San José, California. 27-29 DE ENERO DE 2009