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Memorias de investigación
Artículos en revistas:
A New Model of Synthetic Genetic Oscillator Based on Trans-Acting Repressor Ribozyme
Año:2009
Áreas de investigación
  • Inteligencia artificial
Datos
Descripción
We present a new model of synthetic genetic oscillator based on a typical motif with one positive and one negative feedback loop. The repressor is a ribozyme, rather than a protein, which acts post-transcriptionally binding and cleaving to target mRNA. The properties of the ribozyme simplify our genetic oscillator that involves only two genes, one mRNA and one activator protein, apart from the ribozyme. Moreover, the genetic oscillator generates limit cycle oscillations, essential condition for resist the effects of the stochastic fluctuations due to the inherent randomness of the chemical reactions. As example of operation, we have chosen parameter values that produce circadian period in both deterministic and stochastic simulations, and the effects of stochastic fluctuations are quantified by a period histogram and autocorrelation function. Such new biochemical network designs may yield both new behaviors and better understanding of cellular processes.
Internacional
Si
JCR del ISI
No
Título de la revista
Lecture notes in computer science
ISSN
0302-9743
Factor de impacto JCR
0
Información de impacto
Volumen
5518
DOI
http://dx.doi.org/10.1007/978-3-642-02481-8_177
Número de revista
0
Desde la página
1170
Hasta la página
1177
Mes
JUNIO
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Jesús María Miró Bueno (UPM)
  • Autor: Alfonso Vicente Rodriguez-Paton Aradas (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Inteligencia Artificial (LIA)
  • Departamento: Inteligencia Artificial
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