Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Leishmania donovani: thionins, plant antimicrobial peptides with leishmanicidal activity
Año:2009
Áreas de investigación
  • Microbiología
Datos
Descripción
The leishmanicidal activity of plant antibiotic peptides (PAPs) from the principal families, such wheat thionins, a barley lipid transfer protein and potato defensins and snakins were tested in vitro against Leishmania donovani. Only thionins and defensins were active against this human pathogen at a low micromolar range of concentrations. Thionins resulted as the most active peptides tested until now. They collapsed ionic and pH gradients across the parasite plasma membrane together with a rapid depletion of intracellular ATP without affecting mitochondrial potential. Hence the lethal effect of thionins was mostly associated to permeabilization of the plasma membrane leading to an immediate death of the parasite. The present work is the first evidence for leishmanicidal activity in plant peptides. Future prospects for their development as new antiparasite agents on human diseases are considered.
Internacional
Si
JCR del ISI
Si
Título de la revista
EXPERIMENTAL PARASITOLOGY
ISSN
0014-4894
Factor de impacto JCR
1,751
Información de impacto
Volumen
122
DOI
Número de revista
0
Desde la página
247
Hasta la página
249
Mes
ENERO
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Pablo Rodriguez Palenzuela (UPM)
  • Autor: Antonio Molina Fernandez (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Interacciones Moleculares Planta-Patógeno
  • Departamento: Biotecnología
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