Observatorio de I+D+i UPM

Memorias de investigación
Plant innate immunity and resistance to necrotrophic pathogens: at the cell wall and beyond
Áreas de investigación
  • Biología molecular
The cell wall provides a passive barrier against pathogens and pests, constitutes a reservoir of antimicrobial compounds and is a source of signalling molecules. During plant development or microbial infection cellwall perturbations occur that lead to changes in gene expression. The characterization of plant resistance to necrotrophic and vascular pathogens has revealed the relevance of cell wall in the regulation of Arabidopsis thaliana immune responses. Thus, mutants (e.g. ern1/irx1) impaired in Cellulose synthases (CESAs) required for the synthesis of cellulose from secondary cell wall shows a constitutive activation of ABA-signalling pathway and accumulate a diverse set of antimicrobial compounds, which lead to a broad spectrum resistance to pathogens. To determine the relevance of cell wall in plant innate immunity, biased resistance screenings of additional Arabidopsis cell wall mutants were performed, and novel signal transduction pathways and regulatory proteins controlling plant innate immunity were identified. Among these regulatory proteins, several Receptor-Like-Kinases (RLKs), such as ERECTA, and a Mitogen-Activated Protein Kinase Kinas Kinase (MAP3K) were characterized. Plant RLKs have been suggested to be important components of the cell-wall monitoring integrity pathway, and to regulate basal resistance to pathogens by controlling the recognition of microbial patterns. MAP3Ks regulate RLKs-mediated innate immunity response by activating MAP Kinase cascades. The genetic interaction among these novel components of innate immunity as well as the recent data describing the characterization of the specific interconnection between cell wall integrity and activation of plant innate immunity will be presented.
Entidad relacionada
Nacionalidad Entidad
Sin nacionalidad
Lugar del congreso
Esta actividad pertenece a memorias de investigación
  • Autor: Antonio Molina Fernandez (UPM)
  • Autor: Lucia Jorda Miro (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Interacciones Moleculares Planta-Patógeno
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Biotecnología
S2i 2021 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)