|
Descripción
|
|
|---|---|
| In plant innate immunity, the surface-exposed leucine-rich repeat receptor kinases EFR and FLS2 mediate recognition of the bacterial pathogen-associated molecular patterns EF-Tu and flagellin, respectively. We identified the Arabidopsis stromal-derived factor-2 (SDF2) as being required for EFR function, and to a lesser extent FLS2 function. SDF2 resides in an endoplasmic reticulum (ER) protein complex with the Hsp40 ERdj3B and the Hsp70 BiP, which are components of the ER-quality control (ER-QC). Loss of SDF2 results in ER retention and degradation of EFR. The differential requirement for ER-QC components by EFR and FLS2 could be linked to N-glycosylation mediated by STT3a, a catalytic subunit of the oligosaccharyltransferase complex involved in co-translational N-glycosylation. Our results show that the plasma membrane EFR requires the ER complex SDF2¿ ERdj3B¿BiP for its proper accumulation, and provide a demonstration of a physiological requirement for ER-QC in transmembrane receptor function in plants. They also provide an unexpected differential requirement for ER-QC and N-glycosylation components by two closely related receptors | |
|
Internacional
|
Si |
|
JCR del ISI
|
Si |
|
Título de la revista
|
EMBO JOURNAL |
|
ISSN
|
0261-4189 |
|
Factor de impacto JCR
|
8,295 |
|
Información de impacto
|
|
|
Volumen
|
28 |
|
DOI
|
|
|
Número de revista
|
0 |
|
Desde la página
|
3428 |
|
Hasta la página
|
3438 |
|
Mes
|
ENERO |
|
Ranking
|
|