Observatorio de I+D+i UPM

Memorias de investigación
Tesis:
Optimización de procesos de adquisición de conocimiento en Biología Computacional
Año:2010
Áreas de investigación
  • Inteligencia artificial
Datos
Descripción
Traditionally, clinical data have been the only source of information for disease diagnosis. Today, there are other types of information such as DNA microarrays, which are taken into account to improve diagnosis and prognosis of many diseases. This thesis proposes a new approach, called CliDaPa, to efficiently combine both sources of information (clinical and genetic data), in order to further improve estimations. In this approach, patients are firstly segmented using a tree representation through their clinical data (clinical tree). Therefore, different groups of patients are identified according to similar behavior. Then each individual group is studied with data mining techniques, using the genetic information. To demonstrate its validity, the method is applied to different real data sets (breast and brain cancer). The validation of the results is based on two methods of validation, internal and external, using the Supercomputing and Visualization Centre of Madrid (CeSViMa), where the three approaches of the algorithm were implemented in parallel. The results are compared with other literature studies, as well as traditional analysis techniques, demonstrating a significant improvement over existing results.
Internacional
No
ISBN
Tipo de Tesis
Doctoral
Calificación
Sobresaliente cum laude
Fecha
18/10/2010
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Santiago González Tortosa (UPM)
  • Director: Fazel Famili
  • Director: Victor Robles Forcada (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: COMPUTATIONAL INTELLIGENCE GROUP
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2021 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)