Memorias de investigación
Artículos en revistas:
A Simulation Study of an Inverse Controller for Closed and Semiclosed-Loop Control in Type 1 Diabetes
Año:2010
Áreas de investigación
  • Salud
Datos
Descripción
Background: Closed-loop control algorithms in diabetes aim to calculate the optimum insulin delivery to maintain the patient in a normoglycemic state, taking the blood glucose level as the algorithm¿s main input. The major difficulties facing these algorithms when applied subcutaneously are insulin absorption time and delays in measurement of subcutaneous glucose with respect to the blood concentration. Methods: This article presents an inverse controller (IC) obtained by inversion of an existing mathematical model and validated with synthetic patients simulated with a different model and is compared with a proportionalintegral- derivative controller. Results: Simulated results are presented for a mean patient and for a population of six simulated patients. The IC performance is analyzed for both full closed-loop and semiclosed-loop control. The IC is tested when initialized with the heuristic optimal gain, and it is compared with the performance when the initial gain is deviated from the optimal one (10%). Conclusions: The simulation results show the viability of using an IC for closed-loop diabetes control. The IC is able to achieve normoglycemia over long periods of time when the optimal gain is used (63% for the full closedloop control, and it is increased to 96% for the semiclosed-loop control).
Internacional
Si
JCR del ISI
Si
Título de la revista
Diabetes Technology AND Therapeutics
ISSN
1520-9156
Factor de impacto JCR
2,62
Información de impacto
Volumen
12
DOI
10.1089/dia.2009.0093
Número de revista
12
Desde la página
95
Hasta la página
104
Mes
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Participantes
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Departamento: Sistemas Electrónicos y de Control
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB