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Descripción
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| ACTION-Grid has been the first European Commission (EC)-funded initiative analyzing Nanoinformatics and its relationship with areas such as Biomedical Informatics (BMI) and Nanomedicine. This analysis was aimed towards helping develop a roadmap for future research, which has been the goal of the ACTION Grid project and the White Paper delivered to the EC. As a summary of this White Paper, we suggested: 1. A summary of concrete actions that could be adopted by research agencies ¿and, in particular, the EC¿ to foster new developments in Nanoinformatics. 2. To propose five Grand Challenges in Nanoinformatics, directly connected to BMI, which could lead to strong research results in the mid- and long- term. · Research on data, repositories and standards, regarding a Nanoinformatics infrastructure for collecting, curating, annotating, organizing and archiving the available data. · Interoperability (semantic search, ontologies): structuring nanomedical knowledge is essential for advancing research. Developing new ontologies at the nano level and linking them with other ¿e.g., from the OBO foundry¿will facilitate future interoperability of different information systems containing nano-related data. · Linking nano-related data to Electronic Health Records. For instance, new standards for storing data or augmenting clinical vocabularies and terminologies ¿like SNOMED¿ or for messaging ¿like HL7¿ can incorporate nano-related terminologies and procedures, taking into account patient safety and possible secondary effects of nanoparticles. · Translational Nanoinformatics. A broad, integrative vision of BMI helps integrate molecular and clinical data for scientific discovery. From such a viewpoint, translational nanoinformatics¿ requires a deeper perspective beyond current approaches to informatics, commonly linked to collecting, representing and linking information and managing system and semantic heterogeneity. Basic scientific research at the nano level ¿e.g., quantum dots for imaging applications¿ will surely lead to new clinical applications. · Extension of the European Virtual Physiological Human framework to the nano level. The VPH programme was designed for supporting R&D of patient-specific computer models and informatics tools for modeling and simulating human physiology and disease processes. In addition, there is the need to create catalogues of nanoparticles and biological targets, their interactions and potential nanotoxicity. In this context, BMI and VPH researchers have created a large number of models and simulation tools that could be reused or adapted to nanomedicine. Finally, Nanoinformatics research carried out by members of this consortium include those related to text mining approaches for a variety of topics, like extracting nanotoxicity information from the literature, linking ontologies from the Nanoinformatics area with those from other areas ¿like the OBO Foundry¿ and creating repositories of various types of information that can be used for additional research, information management and analytical efforts in Nanoinformatics and Nanomedicine. | |
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Internacional
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Si |
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Entidad
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National Nanomanufacturing Network |
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Lugar
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ARLINGTON |
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Páginas
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25-26 |
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Referencia/URL
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Nanoinformatics in Europe |
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Tipo de publicación
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Nanoinformatics 2010 |