{"id":11553,"date":"2022-11-11T12:07:21","date_gmt":"2022-11-11T11:07:21","guid":{"rendered":"https:\/\/www.upm.es\/recursosidi\/offers-resources\/sin categor\u00eda\/onco-rec-to-predict-cancer-relapse-detect-minories\/"},"modified":"2022-11-11T12:07:24","modified_gmt":"2022-11-11T11:07:24","slug":"onco-rec-to-predict-cancer-relapse-detect-minories","status":"publish","type":"product","link":"https:\/\/www.upm.es\/recursosidi\/en\/offers-resources\/technological-solutions\/onco-rec-to-predict-cancer-relapse-detect-minories\/","title":{"rendered":"Onco-Rec. To predict cancer relapse, detect minories"},"content":{"rendered":"<h4><strong>Brief description of the technology solution and the added value it provides <\/strong><\/h4>\n<p class=\"MsoNormal\">An algorithm based on the presence of different markers has been designed. These markers are present in tumor-initiating cell (TICs), which could be involved in cancer relapse . These cells are not totally remove in a conventional chemotherapy treatment. Our diagnostic technology &nbsp;is applicable to peripheral blood samples drawn with the usual procedures in the follow-up of patients. The sample is analyzed by flow cytometry techniques, which is included in common routines in hospitals, and at an accessible cost for its standardization. It has allowed us to anticipate the relapse, so if we detect these cells, we can predict that this process is going to happen with a sensibility and specificity higher to the conventional actual methods.&nbsp;<\/p>\n<h4><strong>Description of the technological base<\/strong><\/h4>\n<p>Onco-Rec is a combination of molecular markers expression, integrated as an algorithm, witch allow us the detection of tumour-initiating cells (TICs), considering the tumour heterogeneity.<\/p>\n<p>TICs have a different behaviour with respect to the rest of the tumour cells and they can not be removed by a chemotherapy treatment. The population of TICs in peripheral blood through which they will travel great distances to produce metastasis, can easily be below the detection thresholds of conventional diagnostic methods. But unfortunately, they are the potential culprits of relapse in patients. Different markers (which are included in our algorithm) have been describe to &nbsp;phenotype these cells. With Onco-Rec, we can detect TICs with the usual procedures of the patient and the health personnel.<\/p>\n<p>This algorithm makes it possible to reduce the price in the current market test and since it can be implemented in the routine practices of the hospital center, it will not be necessary for an expert in the technique to develop it, facilitating the daily management.<\/p>\n<p style=\"text-align: center\"><em><strong><span style=\"font-size: small\">&ldquo;The detection of tumor-initiatng cells, as a system to predict cancer relapse&rdquo;<\/span><\/strong><\/em><\/p>\n<p style=\"text-align: center\"><em><strong><span style=\"font-size: small\"><img fetchpriority=\"high\" decoding=\"async\" src=\"http:\/\/www.upm.es\/observatorio\/vi\/gestor_general\/recuperar_archivo.jsp?id=1504\" alt=\"\" width=\"350\" height=\"367\" \/><\/span><\/strong><\/em><\/p>\n<h4><strong>Market demands<\/strong><\/h4>\n<p><strong>Health<\/strong><\/p>\n<ul>\n<li>The number of global cancer cases from 2012 to 2030 will increase by up 50%.<\/li>\n<li>35% of patients suffer relapses despite advances in treatments in effectiveness and side effects decreased<\/li>\n<li>TICs are resistant to conventional drugs in cancer treatment.<\/li>\n<li>The detection of TICs in Spain is made with CELLSEARCH Veridex of Johnson &amp; Johnson&reg; technology, and in spite of detect these cells in blood, it not have high sensibility.<\/li>\n<li>The relapse make tumors more agresive and mortal.<\/li>\n<li>TICS in blood are the totally resposable of metastasis, which is one of the principal cause of the c&aacute;ncer deaths.<\/li>\n<\/ul>\n<p><strong>Biomedical research field<\/strong><\/p>\n<ul>\n<li>The number of potential cancer stem cell markers increase every day but non of them have enougth specificity and sensibility.<\/li>\n<\/ul>\n<p style=\"text-align: center\"><span style=\"font-size: small\"><em><strong>&nbsp;&ldquo;The detection of TICs anticipate the relapse and met&aacute;stasis, which causes the death of c&aacute;ncer patients&rdquo;<\/strong><\/em><\/span><\/p>\n<h4><strong>Competitive advantages<\/strong><\/h4>\n<ul>\n<li>We get a specificity of 90% with a sensitivity of 97%.<\/li>\n<li>We anticipate the relapse is almost two years of 80% of patients and 7 months in all the population analyzed.<\/li>\n<li>The test is done in hospital routine processes and does not need additional specialized technical personnel.<\/li>\n<li>For the patient, the test does not imply an additional procedure, is within the routine follow-up.<br \/>Decrease of costs in the test.<\/li>\n<\/ul>\n<p style=\"text-align: center\"><span style=\"font-size: small\"><em><strong>&nbsp;&ldquo;Anticipation to relapse in almost two years in 80% of patients&rdquo;<\/strong><\/em><\/span><\/p>\n<h4><strong>Previous references<\/strong><\/h4>\n<ul>\n<li>We compare the same patients samples with our tecnology and with CELLSEARCH Veridex of Johnson &amp; Johnson&reg;. We made it with 44 colorectal cancer patients and 20 breast cancer patients, in Albacete Universitary Hospital and Clinico San Carlos Hospital of Madrid.<\/li>\n<\/ul>\n<h4><strong>Development stage<\/strong><\/h4>\n<ul>\n<li><span style=\"font-size: small\">Concept<\/span><\/li>\n<li><span style=\"font-size: small\">R &amp; D<\/span><\/li>\n<li><span style=\"text-decoration: underline\"><strong><span style=\"font-size: small\">Lab Prototype<\/span><\/strong><\/span><\/li>\n<li><span style=\"font-size: small\">Industrial Prototype<\/span><\/li>\n<li><span style=\"font-size: small\">Production<\/span><\/li>\n<\/ul>\n<h4>Contact<\/h4>\n<p class=\"MsoNormal\"><strong><span style=\"font-size: small\">Contacto soluci&oacute;n tecnol&oacute;gica<\/span><\/strong><\/p>\n<p class=\"MsoNormal\"><span style=\"font-size: small\">Aina Catalina Mesquida Marcos; e: <span rel=\"89312d30ab313131ba311b3179312931bd311e31a8313331af311931a1310a30af312d31b1313031b9311d3180312431a3312531b4311e31b331243164311e31c8311f3178312d31bf31\" class=\"cryptex \" style=\"\"><span class=\"CryptexImg ctxeSj2baa4_Jwjb_oZgWU-MH5QZcLY4UWSQPExuZ0BGWk\"><\/span><\/span><\/span><\/p>\n<p class=\"MsoNormal\"><span style=\"font-size: small\"> Carmen Ram&iacute;rez-Castillejo; e: <span rel=\"89312d30b7312931be312331ac312031bd3117319a311f31b8312231a531363170313e31a0313a31b3311c31a5313d3177312531b7311d3172311631a931\" class=\"cryptex \" style=\"\"><span class=\"CryptexImg ctxAdaQE8VeqRoe-TxjPc2z19-j1I272CKDk8pPOqsZ-dE\"><\/span><\/span><\/span>&nbsp;<\/p>\n<p class=\"MsoNormal\"><strong><span style=\"font-size: small\">Contacto UPM<\/span><\/strong><\/p>\n<p class=\"MsoNormal\"><span style=\"font-size: small\">&Aacute;rea de Innovaci&oacute;n, Comercializaci&oacute;n y Creaci&oacute;n de Empresas<\/span><\/p>\n<p class=\"MsoNormal\"><span style=\"font-size: small\">Centro de Apoyo a la Innovaci&oacute;n Tecnol&oacute;gica &ndash; UPM<\/span>&nbsp;<\/p>\n<p class=\"MsoNormal\"><span style=\"font-size: small\">e: <span rel=\"89312d30b3313631ba312931c1311d31bb311431a6312c3174312931a5312b31b0313b31ab313c31b1311331a331243177312531b7311d3172311631a931\" class=\"cryptex \" style=\"\"><span class=\"CryptexImg ctxR7neImVV1tJoTSyttUGBAuiESKXKLLyzTwJSN1lk9Z0\"><\/span><\/span><\/span><\/p>\n<div class=\"pdfprnt-buttons pdfprnt-buttons-product pdfprnt-bottom-left\"><a href=\"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/product\/11553?print=pdf\" class=\"pdfprnt-button pdfprnt-button-pdf\" target=\"_blank\"><span class=\"pdfprnt-button-title pdfprnt-button-pdf-title\">Descargar ficha<\/span><\/a><\/div>","protected":false},"excerpt":{"rendered":"<p>Detection of potential tumor-initiating cells (TICs) in peripheral blood to anticipate the relapse in breast and colorectal cancer.\u00a0<\/p>\n","protected":false},"featured_media":11552,"template":"","meta":{"_acf_changed":false},"product_cat":[2386],"product_tag":[8579,2479,8581,6576],"comunidades-upm":[],"quien":[],"mapa":[{"term_id":38,"name":"Health and Wellbeing","slug":"health-and-wellbeing","term_group":0,"term_taxonomy_id":38,"taxonomy":"mapa","description":"","parent":0,"count":51,"filter":"raw","term_order":"18"}],"disponibilidad":[{"term_id":205,"name":"Consultar disponibilidad","slug":"consultar","term_group":0,"term_taxonomy_id":205,"taxonomy":"disponibilidad","description":"","parent":0,"count":290,"filter":"raw","term_order":"0"}],"donde":[{"term_id":1842,"name":"Health Sciences Technologies","slug":"en_health-sciences-technologies","term_group":0,"term_taxonomy_id":1842,"taxonomy":"donde","description":"","parent":0,"count":7,"filter":"raw","term_order":"0"},{"term_id":620,"name":"Tecnolog\u00edas para Ciencias de la Salud","slug":"tecnologias-para-ciencias-de-la-salud","term_group":0,"term_taxonomy_id":620,"taxonomy":"donde","description":"","parent":0,"count":21,"filter":"raw","term_order":"0"}],"infraestructura":[],"ods":[{"term_id":2273,"name":"Good Health and Well-Being","slug":"good-health-and-well-being","term_group":0,"term_taxonomy_id":2273,"taxonomy":"ods","description":"","parent":0,"count":54,"filter":"raw","term_order":"0"}],"origen":[{"term_id":192,"name":"Soluciones tecnol\u00f3gicas","slug":"soluciones-tecnologicas","term_group":0,"term_taxonomy_id":192,"taxonomy":"origen","description":"","parent":0,"count":278,"filter":"raw","term_order":"0"}],"familia_tax":false,"quien_tax":false,"donde_tax":false,"year":"2020-01-01","contacto":"ETSI Agron\u00f3mica, Alimentaria y de Biosistemas, Av. Puerta de Hierro, n\u00ba 2 - 4, 28040 Madrid","telefono":"910670742","pagina_web":"http:\/\/www.etsiaab.upm.es\/","email":"mariadelcarmen.ramirez@upm.es","id_ficha_portal":"88","video":"","adjuntos":false,"adjuntos_portal":"","inf":false,"departamento":"","acf":[],"lang":"en","translation":{"en":11553,"es":11551},"_links":{"self":[{"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/product\/11553"}],"collection":[{"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/media\/11552"}],"wp:attachment":[{"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/media?parent=11553"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/product_cat?post=11553"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/product_tag?post=11553"},{"taxonomy":"comunidad_upm","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/comunidades-upm?post=11553"},{"taxonomy":"quien","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/quien?post=11553"},{"taxonomy":"mapa","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/mapa?post=11553"},{"taxonomy":"disponibilidad","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/disponibilidad?post=11553"},{"taxonomy":"donde","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/donde?post=11553"},{"taxonomy":"infraestructura","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/infraestructura?post=11553"},{"taxonomy":"ods","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/ods?post=11553"},{"taxonomy":"origen","embeddable":true,"href":"https:\/\/www.upm.es\/recursosidi\/wp-json\/wp\/v2\/origen?post=11553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}