Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Ensemble transcript interaction networks: A case study on Alzheimer's disease
Year:2012
Research Areas
  • Artificial intelligence,
  • Insanity senile (alzheimer, parkinson)
Information
Abstract
Systems biology techniques are a topic of recent interest within the neurological field. Computational intelligence (CI) addresses this holistic perspective by means of consensus or ensemble techniques ultimately capable of uncovering new and relevant findings. In this paper, we propose the application of a CI approach based on ensemble Bayesian network classifiers and multivariate feature subset selection to induce probabilistic dependences that could match or unveil biological relationships. The research focuses on the analysis of high-throughput Alzheimer's disease (AD) transcript profiling. The analysis is conducted from two perspectives. First, we compare the expression profiles of hippocampus subregion entorhinal cortex (EC) samples of AD patients and controls. Second, we use the ensemble approach to study four types of samples: EC and dentate gyrus (DG) samples from both patients and controls. Results disclose transcript interaction networks with remarkable structures and genes not directly related to AD by previous studies. The ensemble is able to identify a variety of transcripts that play key roles in other neurological pathologies. Classical statistical assessment by means of non-parametric tests confirms the relevance of the majority of the transcripts. The ensemble approach pinpoints key metabolic mechanisms that could lead to new findings in the pathogenesis and development of AD.
International
Si
JCR
Si
Title
Computer Methods And Programs in Biomedicine
ISBN
0169-2607
Impact factor JCR
1,238
Impact info
Datos JCR del año 2010
Volume
108
10.1016/j.cmpb.2011.11.011
Journal number
1
From page
442
To page
450
Month
SIN MES
Ranking
Participants
  • Autor: Ruben Armañanzas Arnedillo (UPM)
  • Autor: Pedro Maria Larrañaga Mugica (UPM)
  • Autor: Maria Concepcion Bielza Lozoya (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: COMPUTATIONAL INTELLIGENCE GROUP
  • Departamento: Inteligencia Artificial
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)