Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints
Año:2012
Áreas de investigación
  • Bioinstrumentación,
  • Tecnología electrónica y de las comunicaciones
Datos
Descripción
It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects.
Internacional
Si
JCR del ISI
Si
Título de la revista
Age
ISSN
0161-9152
Factor de impacto JCR
3,948
Información de impacto
Volumen
34
DOI
Número de revista
2
Desde la página
497
Hasta la página
506
Mes
ABRIL
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Nazareth Perales Castellanos (UPM)
  • Autor: Ricardo Bajo Breton (UPM)
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: FERNANDO MAESTU (UCM)
  • Autor: SARA AUTERNETXE
  • Autor: Mª EUGENIA LOPEZ (UCM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2018 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)