Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints
Year:2012
Research Areas
  • Bioinstrumentation,
  • Electronic technology and of the communications
Information
Abstract
It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects.
International
Si
JCR
Si
Title
Age
ISBN
0161-9152
Impact factor JCR
3,948
Impact info
Volume
34
Journal number
2
From page
497
To page
506
Month
ABRIL
Ranking
Participants
  • Autor: Nazareth Perales Castellanos (UPM)
  • Autor: Ricardo Bajo Breton (UPM)
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: FERNANDO MAESTU (UCM)
  • Autor: SARA AUTERNETXE
  • Autor: Mª EUGENIA LOPEZ (UCM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)