Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
Thermal and mechanical effects of different excitation modes based on low frequency laser modulation in optical hyperthermia
Research Areas
  • Physics chemical and mathematical,
  • Natural sciences and health sciences,
  • Biomedicine,
  • Electronic technology and of the communications
The low frequency modulation of the laser source (<30KHz) allows the generation of a pulsed signal that intermittently excites the gold nanorods. The temperature curves obtained for different frequencies and duty cycles of modulation but with equal average power and identical laser parameters, show that the thermal behavior in continuous wave and modulation modes is the same. However, the cell death experiments suggest that the percentage of death is higher in the cases of modulation. This observation allows us to conclude that there are other effects in addition to temperature that contribute to the cellular death. The mechanical effects like sound or pressure waves are expected to be generated from thermal expansion of gold nanorods. In order to study the behavior and magnitude of these processes we have developed a measure device based on ultrasound piezoelectric receivers (25KHz) and a lock-in amplifier that is able to detect the sound waves generated in samples of gold nanorods during laser irradiation providing us a voltage result proportional to the pressure signal. The first results show that the pressure measurements are directly proportional to the concentration of gold nanorods and the laser power, therefore, our present work is focused on determine the real influence of these effects in the cell death process.
Trends in Nanotechnology (TNT)
Start Date
End Date
From page
To page
TNT 2012 Proceedings
  • Autor: Cristina Sanchez Lopez de Pablo (UPM)
  • Autor: Julio Alberto Ramos Ávila (UPM)
  • Autor: Tamara Fernáncez Cabada (UPM)
  • Autor: Milagros Ramos Gomez (UPM)
  • Autor: Alberto Martínez (CBM)
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: Jose Javier Serrano Olmedo (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Tecnología Electrónica
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)