Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Musical Representation of Dendritic Spine Distribution: A New Exploratory Tool
Year:2014
Research Areas
  • Computational biology,
  • Computer system,
  • Interactivity
Information
Abstract
Dendritic spines are small protrusions along the dendrites of many types of neurons in the central nervous system and represent the major target of excitatory synapses. For this reason, numerous anatomical, physiological and computational studies have focused on these structures. In the cerebral cortex the most abundant and characteristic neuronal type are pyramidal cells (about 85 % of all neurons) and their dendritic spines are the main postsynaptic target of excitatory glutamatergic synapses. Thus, our understanding of the synaptic organization of the cerebral cortex largely depends on the knowledge regarding synaptic inputs to dendritic spines of pyramidal cells. Much of the structural data on dendritic spines produced by modern neuroscience involves the quantitative analysis of image stacks from light and electron microscopy, using standard statistical and mathematical tools and software developed to this end. Here, we present a new method with musical feedback for exploring dendritic spine morphology and distribution patterns in pyramidal neurons. We demonstrate that audio analysis of spiny dendrites with apparently similar morphology may ?sound? quite different, revealing anatomical substrates that are not apparent from simple visual inspection. These morphological/music translations may serve as a guide for further mathematical analysis of the design of the pyramidal neurons and of spiny dendrites in general.
International
Si
JCR
Si
Title
Neuroinformatics
ISBN
1539-2791
Impact factor JCR
2,973
Impact info
Datos JCR del año 2011, Primer Cuartil
Volume
10.1007/s12021-013-9195-0
Journal number
From page
1
To page
13
Month
SIN MES
Ranking
Participants
  • Autor: Pablo Toharia (Universidad Rey Juan Carlos)
  • Autor: Juan Morales Del Olmo (UPM)
  • Autor: Octavio de Juan (Conservatorio Profesional Guitarrista José Tomás de Alicante, Alicante, Spain)
  • Autor: Isabel Fernaud (Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica)
  • Autor: Angel Rodriguez Mtnez.de Bartolome (UPM)
  • Autor: Javier DeFelipe (Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Arquitectura y Tecnología de Sistemas Informáticos
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)