Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Vertical transmission selects for reduced virulence in a plant virus and for increased resistance in the host
Year:2014
Research Areas
  • Phytopathology,
  • Viral pathogens of plants
Information
Abstract
Virulence is a key property of parasites, and is linked to the emergence of new diseases and to the reduction of ecosystem biodiversity. Consequently, scientists have devoted a great effort to build theoretical models that predict which factors may modulate virulence evolution. However, whether (and how) these factors affect virulence evolution has been seldom analysed experimentally. Using the plant virus Cucumber mosaic virus (CMV) and its natural host Arabidopsis thaliana, we studied the role of two such factors: the mode of transmission, and host adaptation in response to parasite evolution. We serially passaged CMV under strict vertical and strict horizontal transmission, and a combination of both. Subsequently, we analysed differences in CMV seed (vertical) transmission rate, accumulation and virulence between evolved and non-evolved viruses. We also compared whether these differences varied in original plants and in plants evolved during vertical passaging. Vertical passaging increased CMV seed transmission, and reduced accumulation and virulence, while horizontal passaging had no effect. Changes during vertical passaging were determined also by reciprocal host adaptation, which additionally reduced virulence and accumulation of vertically transmitted viruses. Hence, we provide evidence that the interplay between the transmission mode and host-parasite co-evolution is central in determining virulence evolution.
International
Si
JCR
Si
Title
Plos Pathogens
ISBN
1553-7374
Impact factor JCR
8,057
Impact info
Volume
10
Journal number
From page
e1004293
To page
e1004293
Month
SIN MES
Ranking
Participants
  • Autor: Jesus Israel Pagan Muñoz (UPM)
  • Autor: Nuria Montes Casado (UPM)
  • Autor: Michael G. Milgroom (Cornell University, Ithaca, NY. USA)
  • Autor: Fernando Garcia-Arenal Rodriguez (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Patología Vegetal
  • Departamento: Biotecnología - Biología Vegetal
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)