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Descripción
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| The dynamics of pathogen infection in host populations, and the evolution of virulence and infectivity, has been extensively analysed using simple deterministic models. Developments of initial models include analyses of the host, pathogen and environment factors that may determine pathogen prevalence and evolution, and hypotheses on pathogen evolution or on host-pathogen co-evolution have been tested by simulation of a diversity of conditions. This work has contributed very significantly to advance theory by generating hypotheses and predictions. However, it has the limitation that often the model assumptions have not been tested experimentally, or that key model parameters vary within an unknown range of values, or that the hypotheses developed through modelling are not testable empirically or experimentally. A major interest of our research group is to analyse the outcome of pathogen evolution and host-pathogen co-evolution under realistic assumptions using models that allow simulations of conditions that cannot be tested empirically. For models and assumptions to be realistic we have devoted important efforts to collect epidemiological data from real, field epidemics, and to estimate experimentally model parameters and their variation according to host and pathogen genotypes. We use plant-virus systems, which allow to take advantage of plant traits (from sessility in the field to the ethics and economy of experimentation) for field and laboratory work. We will present work illustrating our current interests, as well as the contributions, and limitations, of our modelling approaches. | |
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Internacional
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Si |
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ISSN o ISBN
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000-00-0000-000-0 |
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Entidad relacionada
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Nacionalidad Entidad
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ESPAÑA |
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Lugar del congreso
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Barcelona |