Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
A computational model coupling mechanics and electrophysiology in spinal cord injury
Year:2014
Research Areas
  • Engineering
Information
Abstract
Traumatic brain injury and spinal cord injury have recently been put under the spotlight as major causes of death and disability in the developed world. Despite the important ongoing experimental and modeling campaigns aimed at understanding the mechanics of tissue and cell damage typically observed in such events, the differentiated roles of strain, stress and their corresponding loading rates on the damage level itself remain unclear. More specifically, the direct relations between brain and spinal cord tissue or cell damage, and electrophysiological functions are still to be unraveled. Whereas mechanical modeling efforts are focusing mainly on stress distribution and mechanistic-based damage criteria, simulated function-based damage criteria are still missing. Here, we propose a new multiscale model of myelinated axon associating electrophysiological impairment to structural damage as a function of strain and strain rate. This multiscale approach provides a new framework for damage evaluation directly relating neuron mechanics and electrophysiological properties, thus providing a link between mechanical trauma and subsequent functional deficits
International
Si
JCR
Si
Title
Biomechanics And Modeling in Mechanobiology
ISBN
1617-7959
Impact factor JCR
3,251
Impact info
Datos JCR del año 2013
Volume
13
10.1007/s10237-013-0543-7
Journal number
4
From page
883
To page
896
Month
AGOSTO
Ranking
Q1
Participants
  • Autor: Antoine Jérusalem (University of Oxford)
  • Autor: Julian Andres Garcia Grajales (UPM)
  • Autor: Angel Merchán-Pérez (Universidad Politécnica de Madrid)
  • Autor: Jose Maria Peña Sanchez (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Minería de Datos y Simulación (MIDAS)
  • Departamento: Arquitectura y Tecnología de Sistemas Informáticos
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)