Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion
Year:2015
Research Areas
  • Natural sciences and health sciences
Information
Abstract
A constant challenge in experimental stroke is the use of appropriate tests to identify signs of recovery and adverse effects linked to a particular therapy. In this study, we used a long-term longitudinal approach to examine the functional brain changes associated with cortical infarction in a mouse model induced by permanent ligation of the middle cerebral artery (MCA). Sensorimotor function and somatosensory cortical activity were evaluated with fault-foot and forelimb asymmetry tests in combination with somatosensory evoked potentials. The stroke mice exhibited both long-term deficits in the functional tests and impaired responses in the infarcted and intact hemispheres after contralateral and ipsilateral forepaw stimulation. In the infarcted hemisphere, reductions in the amplitudes of evoked responses were detected after contralateral and ipsilateral stimulation. In the intact hemisphere, and similar to cortical stroke patients, a gradual hyperexcitability was observed after contralateral stimulation but no parallel evidence of a response was detected after ipsilateral stimulation. Our results suggest the existence of profound and persistent changes in the somatosensory cortex in this specific mouse cortical stroke model. The study of evoked potentials constitutes a feasible and excellent tool for evaluating the fitness of the somatosensory cortex in relation to functional recovery after preclinical therapeutic intervention.
International
Si
JCR
Si
Title
Journal of Cerebral Blood Flow & Metabolism
ISBN
0271-678X
Impact factor JCR
5,407
Impact info
Volume
36
10.1177/0271678X15606139
Journal number
3
From page
606
To page
620
Month
MARZO
Ranking
Participants
  • Autor: Juan Antonio Barios Heredero (UPM)
  • Autor: Milagros Ramos Gomez (UPM)
  • Autor: Daniel Gonzalez Nieto (UPM)
  • Autor: K Pisarchyk
  • Autor: Laura Fernández García (UPM)
  • Autor: LC Barrio
  • Autor: R Martinez-Murillo
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnologías para Ciencias de la Salud
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)