Memorias de investigación
Ponencias en congresos:
Connexin-36 protects against suddent infant death syndrome
Año:2015
Áreas de investigación
  • Ciencias naturales y ciencias de la salud
Datos
Descripción
The sudden infant death syndrome (SIDS) is the main cause of postneonatal infant death; however the etiology of SIDS remains ill defined. The hypothesis that SIDS, or a subset of SIDS, is due to an abnormal brainstem mechanism is one of the current leading hypotheses on SIDS etiology. The brainstem is essential for cardiac and respiratory function, controlling autonomic and homeostatic responses including breathing, central chemosensitivity, heartbeat and blood pressure, all mechanisms that are thought to be involved in SIDS. Connexin-36 (Cx36), the principal component of neuron-to-neuron channels that form the electrical synapses, is present in the specific neural populations of brainstem region involved in the CO2 chemoreception and respiratory control, and its expression is unregulated during this critical period of life. Accordingly, we postulate that Cx36 would be a key element in the pathogenesis of SIDS. To address this issue we have studied how the genetic suppression of Cx36 expression affects to the respiratory pacemaker, central chemoreflexes, cardiorespiratory coupling, and risk for SIDS. Mice lacking Cx36 at postnatal day 14 showed in comparison with control wild-type greater variability in the respiratory rhythmicity, abnormally enhanced ventilatory responses to hypoxia and hypercapnia, more cardiorespiratory phase synchronization and less respiratory sinus arrhythmia. A combination of low O2 and high CO2 content in inspired air was used as exogenous stressor of SIDS; under these conditions all wild-type mice survived while the 40% of Cx36-knockout animals succumbed by respiratory failure.
Internacional
Si
Nombre congreso
5th Spanish Ion Channel Network Meeting (RECI): Present and Future Research in Ion Channel Research
Tipo de participación
970
Lugar del congreso
BARCELONA
Revisores
Si
ISBN o ISSN
0000-0000-00
DOI
Fecha inicio congreso
04/10/2015
Fecha fin congreso
06/10/2015
Desde la página
59
Hasta la página
59
Título de las actas
ABSTRACTS BOOK RECI
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Juan Antonio Barios Heredero UPM
  • Autor: Daniel Gonzalez Nieto UPM
  • Autor: L PEREZ-ATENCIO
  • Autor: LC BARRIO
  • Autor: M ARDAIZ
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Tecnologías para Ciencias de la Salud
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería