Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Altered brain rhythms and functional network disruptions involved in patients with generalized fixation-off epilepsy
Año:2015
Áreas de investigación
  • Ciencias naturales y ciencias de la salud
Datos
Descripción
Generalized Fixation-off Sensitivity (CGE-FoS) patients present abnormal EEG patterns when losing fixation. In the present work, we studied two CGE-FoS epileptic patients with simultaneous EEG-fMRI. We aim to identify brain areas that are specifically related to the pathology by identifying the brain networks that are related to the EEG brain altered rhythms. Three main analyses were performed: EEG standalone, where the voltage fluctuations in delta, alpha, and beta EEG bands were obtained; fMRI standalone, where resting-state fMRI ICA analyses for opened and closed eyes conditions were computed per subject; and, EEG-informed fMRI, where EEG delta, alpha and beta oscillations were used to analyze fMRI. Patient 1 showed EEG abnormalities for lower beta band EEG brain rhythm. Fluctuations of this rhythm were correlated with a brain network mainly composed by temporo-frontal areas only found in the closed eyes condition. Patient 2 presented alterations in all the EEG brain rhythms (delta, alpha, beta) under study when closing eyes. Several biologically relevant brain networks highly correlated (r?>?0.7) to each other in the closed eyes condition were found. EEG-informed fMRI results in patient 2 showed hypersynchronized patterns in the fMRI correlation spatial maps. The obtained findings allow a differential diagnosis for each patient and different profiles with respect to healthy volunteers. The results suggest a different disruption in the functional brain networks of these patients that depends on their altered brain rhythms. This knowledge could be used to treat these patients by novel brain stimulation approaches targeting specific altered brain networks in each patient.
Internacional
Si
JCR del ISI
Si
Título de la revista
Brain Imaging And Behavior
ISSN
1931-7557
Factor de impacto JCR
4,598
Información de impacto
Volumen
DOI
10.1007/s11682-015-9404-6
Número de revista
Desde la página
1
Hasta la página
14
Mes
MAYO
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: AB SOLANA
  • Autor: K MARTINEZ
  • Autor: JA Hernandez-Tamames
  • Autor: V San Antonio-Arce
  • Autor: R TOLEDANO
  • Autor: I GARCIA MORALES
  • Autor: J ALVAREZ LINERA
  • Autor: A GIL NAGEL
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Tecnologías para Ciencias de la Salud
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2018 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)