Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
A fast pathway for fear in human amygdala
Year:2016
Research Areas
  • Natural sciences and health sciences,
  • Clinical medicine and epidemiology,
  • Biomedicine
Information
Abstract
A fast, subcortical pathway to the amygdala is thought to have evolved to enable rapid detection of threat. This pathway's existence is fundamental for understanding nonconscious emotional responses, but has been challenged as a result of a lack of evidence for short-latency fear-related responses in primate amygdala, including humans. We recorded human intracranial electrophysiological data and found fast amygdala responses, beginning 74-ms post-stimulus onset, to fearful, but not neutral or happy, facial expressions. These responses had considerably shorter latency than fear responses that we observed in visual cortex. Notably, fast amygdala responses were limited to low spatial frequency components of fearful faces, as predicted by magnocellular inputs to amygdala. Furthermore, fast amygdala responses were not evoked by photographs of arousing scenes, which is indicative of selective early reactivity to socially relevant visual information conveyed by fearful faces. These data therefore support the existence of a phylogenetically old subcortical pathway providing fast, but coarse, threat-related signals to human amygdala.
International
Si
JCR
Si
Title
Nature Neuroscience
ISBN
1097-6256
Impact factor JCR
16,724
Impact info
Volume
Journal number
From page
1041
To page
1049
Month
SIN MES
Ranking
Participants
  • Autor: Constantino Mendez Bertolo (UPM)
  • Autor: Bryan Strange (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnologías para Ciencias de la Salud
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)