Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma
Year:2016
Research Areas
  • Natural sciences and health sciences
Information
Abstract
Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via T helper 17 (Th17) lymphocytes and interleukin 17A (IL-17A). This induces white adipose tissue neutrophil infiltration mediating insulin resistance (IR) and fatty acid release, stored in liver as triglycerides, causing NASH. NASH and subsequently HCC are prevented by pharmacological suppression of Th17 cell differentiation, IL-17A blocking antibodies, and genetic ablation of the IL-17A receptor in myeloid cells. Human hepatitis, fatty liver, and viral hepatitis-associated HCC exhibit increased IL-17A correlating positively with steatosis. IL-17A blockers may prevent IR, NASH, and HCC in high-risk patients.
International
Si
JCR
Si
Title
Cancer Cell
ISBN
1535-6108
Impact factor JCR
23,214
Impact info
Volume
30
Journal number
From page
161
To page
175
Month
SIN MES
Ranking
Q1
Participants
  • Autor: Ana L Gomes (CNIO)
  • Autor: Ana Teijeiro (CNIO)
  • Autor: Nils Stefan Buren (UPM)
  • Autor: Krishna S Tummala (CNIO)
  • Autor: Mahmut Yilmaz (CNIO)
  • Autor: Ari Waisman (Johannes Gutenberg University of Mainz,)
  • Autor: Jean-Philippe Theurillat (Institute of Oncology Research)
  • Autor: Cristian Pema (Hospital Ramón y Cajal)
  • Autor: Nabil Djouder (CNIO)
Research Group, Departaments and Institutes related
  • Creador: Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)