Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
The ligand of the major peach allergen Pru p 3 is presented to iNKT cells
Year:2018
Research Areas
  • Natural sciences and health sciences,
  • Molecular, cellular and genetic biology,
  • Biological sciences
Information
Abstract
Lipids transported by allergenic proteins have been demonstrated to play a crucial role in the sensitization phase of allergy. Pru p 3, the major allergen from peach fruit, is an nsLTP (nonspecific lipid transport protein) that carries a ligand recently identified in our research group as a hydroxyl derivative of the alkaloid camptothecin bound to a phytosphingosine tail. For its participation into allergy sensitization events, the ligand activates immune responses through CD1d?mediated presentation. The CD1d receptor protein is a member of CD1 molecules that present lipids and glycolipids to the immune system. The family member CD1d is specifically recognized by the T?cell receptor (TCR) of invariant natural killer T?cells (iNKT).
International
Si
Congress
European Academy of Allergy and Clinical Immunology (EAACI), congress 2018.
970
Place
Reviewers
Si
ISBN/ISSN
0105-4538
Start Date
26/05/2018
End Date
30/05/2018
From page
781
To page
781
Special Issue:Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 26?30 May 2018, Munich, Germany
Participants
  • Autor: Maria Garrido Arandia (UPM)
  • Autor: N Cubells
  • Autor: Leticia Tordesillas
  • Autor: Vanesa Esteban
  • Autor: W Barcik
  • Autor: L O¿mahony
  • Autor: Luis Fernandez Pacios (UPM)
  • Autor: Araceli Diaz Perales (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Biotecnología - Biología Vegetal
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)