Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Effects of HIV-1 Proteins on the Fas-Mediated Apoptotic Signaling Cascade: A Computational Study of Latent CD4+ T Cell Activation
Year:2009
Research Areas
  • Artificial intelligence
Information
Abstract
We present a new model for simulating Fas-induced apoptosis in HIV-1-infected CD4+ T cells. Moreover, the reactivation of latently infected cells is explored. The work, an extension of our previous modeling efforts, is the first attempt in systems biology for modeling the Fas pathway in the latently infected cells. These enigmatic cells are considered the last barrier in the elimination of HIV infection. In building the model, we gathered what reaction rates and initial conditions are available from the literature. For the unknown constants, we fit the model to the available information on the observed effects of HIV-1 proteins in activated CD4+ T cells. We provide results, using the Nondeterministic Waiting Time (NWT) algorithm, from the model, simulating the infection of activated CD4+ T cells as well as the reactivation of a latently infected cells. These two model versions are distinct with respect to the initial conditions ¿ multiplicities and locations of proteins at the beginning of the simulation.
International
Si
JCR
No
Title
Lecture notes in computer science
ISBN
0302-9743
Impact factor JCR
0
Impact info
Volume
5391
http://dx.doi.org/10.1007/978-3-540-95885-7_18
Journal number
0
From page
246
To page
259
Month
ENERO
Ranking
Participants
  • Participante: John Jack (Department of Computer Science/IfM, Louisiana Tech University, P.O. Box 10348, Ruston, LA 71272, USA)
  • Autor: Paul Andrei Paun (UPM)
  • Autor: Alfonso Vicente Rodriguez-Paton Aradas (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Inteligencia Artificial (LIA)
  • Departamento: Inteligencia Artificial
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)