Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Comparison between supervised and unsupervised classifications of neuronal cell types: a case study
Year:2010
Research Areas
  • Artificial intelligence
Information
Abstract
In the study of neural circuits, it becomes essential to discern the different neuronal cell types that build the circuit. Traditionally, neuronal cell types have been classified using qualitative descriptors. More recently, several attempts have been made to classify neurons quantitatively, using unsupervised clustering methods. While useful, these algorithms do not take advantage of previous information known to the investigator, which could improve the classification task. For neocortical GABAergic interneurons, the problem to discern among different cell types is particularly difficult and better methods are needed to perform objective classifications. Here we explore the use of supervised classification algorithms to classify neurons based on their morphological features, using a database of 128 pyramidal cells and 199 interneurons from mouse neocortex. To evaluate the performance of different algorithms we used, as a \benchmark," the test to automatically distinguish between pyramidal cells and interneurons, defining \ground truth" by the presence or absence of an apical dendrite. We compared hierarchical clustering with a battery of different supervised classification algorithms, finding that supervised classifications outperformed hierarchical clustering. In addition, the selection of subsets of distinguishing features enhanced the classification accuracy for both sets of algorithms. The analysis of selected variables indicates that dendritic features were most useful to distinguish pyramidal cells from interneurons when compared with somatic and axonal morphological variables. We conclude that supervised classification algorithms are better matched to the general problem of distinguishing neuronal cell types when some information on these cell groups, in our case being pyramidal or interneuron, is known a priori. As a spin-off of this methodological study, we provide several methods to automatically distinguish neocortical pyramidal cells from interneurons, based on their morphologies
International
Si
JCR
Si
Title
Developmental Neurobiology
ISBN
1932-8451
Impact factor JCR
2,732
Impact info
Volume
71
Journal number
1
From page
71
To page
82
Month
JUNIO
Ranking
Participants
  • Autor: Luis Pelayo Guerra Velasco (UPM)
  • Participante: Laura M. McGarry
  • Autor: Victor Robles Forcada (UPM)
  • Participante: Rafael Yuste
  • Autor: Maria Concepcion Bielza Lozoya (UPM)
  • Autor: Pedro Maria Larrañaga Mugica (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: COMPUTATIONAL INTELLIGENCE GROUP
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)