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Descripción
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| We report the identification of the MINIYO (IYO) gene, a positive regulator of transcriptional elongation that is essential for cells to initiate differentiation in Arabidopsis. IYO interacts with RNA polymerase II and the Elongator complex and is required to sustain global levels of transcriptional elongation activity, specifically in differentiating tissues. Accordingly, IYO is expressed in embryos, meristems, and organ primordia and not in mature tissues. Moreover, differential subcellular protein distribution further refines the domain of IYO function by directing nuclear accumulation, and thus its transcriptional activity, to cells initiating differentiation. Importantly, IYO overexpression induces premature cell differentiation and leads to meristem termination phenotypes. | |
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Internacional
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Si |
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JCR del ISI
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Si |
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Título de la revista
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Current Biology |
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ISSN
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0960-9822 |
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Factor de impacto JCR
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9,647 |
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Información de impacto
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Datos JCR del año 2011 |
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Volumen
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21 |
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DOI
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10.1016/j.cub.2011.04.041 |
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Número de revista
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12 |
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Desde la página
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999 |
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Hasta la página
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1008 |
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Mes
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JUNIO |
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Ranking
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