Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Biocircuit design through engineering bacterial logic gates. Natural Computing
Año:2011
Áreas de investigación
  • Ingenierías
Datos
Descripción
Designing synthetic biocircuits to perform desired purposes is a scientific field that has exponentially grown over the past decade. The advances in genome sequencing, bacteria gene regulatory networks, as well as the further knowledge of intraspecies bacterial communication through quorum sensing signals are the starting point for this work. Although biocircuits are mostly developed in a single cell, here we propose a model in which every bacterium is considered to be a single logic gate and chemical cell-to-cell connections are engineered to control circuit function. Having one genetically modified bacterial strain per logic process would allow us to develop circuits with different behaviors by mixing the populations instead of re-programming the whole genetic network within a single strain. Two principal advantages of this procedure are highlighted. First, the fully connected circuits obtained where every cellgate is able to communicate with all the rest. Second, the resistance to the noise produced by inappropriate gene expression. This last goal is achieved by modeling thresholds for input signals. Thus, if the concentration of input does not exceed the threshold, it is ignored by the logic function of the gate.
Internacional
Si
JCR del ISI
Si
Título de la revista
Natural Computing
ISSN
1567-7818
Factor de impacto JCR
Información de impacto
Volumen
DOI
10.1007/s11047-010-9184-2
Número de revista
10
Desde la página
119
Hasta la página
127
Mes
MARZO
Ranking
Cuartil Q2
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Fernando Arroyo Montoro (UPM)
  • Autor: Juan Bautista Castellanos Peñuela (UPM)
  • Autor: Angel Goñi Moreno
  • Autor: Miguel Redondo Nieto (Depto. Biolog¿¿a, Facultad de Ciencias, Universidad Autónoma de Madrid)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Computación Natural
  • Departamento: Lenguajes, Proyectos y Sistemas Informáticos
  • Departamento: Inteligencia Artificial
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