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Abstract
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| Studying the geometry of synaptic junctions enables new hy- potheses to be established regarding chemical communication between neurons. Morphological studies of these structures is greatly facilitated by the use of recent electron microscopy techniques that permit 3D re- construction of large numbers of synapses. Two critical components of the synaptic junction are the active zone and the postsynaptic density, as they are directly related to the synaptic release probability and the num- ber of postsynaptic receptors, respectively. Given that these two struc- tures are in close apposition, they can be represented by a single surface, the synaptic apposition surface. We have developed a technique to auto- matically extract this surface and the features of this structure that are most relevant to researchers interested in studying synaptic function. | |
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International
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Si |
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Congress
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5th Workshop on Data Mining in Functional Genomics and Proteomics: current trends and future directions |
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960 |
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Place
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Atenas, Grecia |
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Reviewers
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Si |
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ISBN/ISSN
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Start Date
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05/09/2011 |
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End Date
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05/09/2011 |
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From page
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63 |
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To page
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72 |
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Proc. of the 5th Workshop on Data Mining in Functional Genomics and Proteomics: current trends and future directions |