Artículos en revistas:
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Año:2012
Áreas de investigación
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Biología molecular, celular y genética
Datos
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Descripción
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| The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens. | |
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Internacional
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Si |
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JCR del ISI
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Si |
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Título de la revista
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Plos One |
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ISSN
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1932-6203 |
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Factor de impacto JCR
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4,092 |
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Información de impacto
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Volumen
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7 |
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DOI
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10.1371/journal.pone.0050799 |
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Número de revista
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12 |
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Desde la página
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1 |
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Hasta la página
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10 |
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Mes
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DICIEMBRE |
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Ranking
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Participantes
- Autor: Aranzazu Palacín Gómez (UPM)
- Autor: Cristina Gomez Casado (UPM)
- Autor: Luis A Rivas (INTA-CSIC)
- Autor: Jacobo Aguirre (Instituto de Investigacio¿n Sanitaria Princesa)
- Autor: Leticia Tordesillas Villuendas (UPM)
- Autor: Joan Bartra (CIBERES)
- Autor: Carlos Blanco (Instituto de Investigacio¿n Sanitaria Princesa)
- Autor: Teresa Carrillo (Hospital Universitario de Gran Canaria Dr. Negrin,)
- Autor: Javier Cuesta Herranz (Fundacion Jimenez Diaz,)
- Autor: Consolación de Frutos (Instituto de Investigacio¿n Sanitaria Princesa)
- Autor: Genoveva Garc¿a Allvarez-Eire (Complexo Hospitalario, Ourense)
- Autor: Francisco J Fernandez (General University Hospital, Miguel Hernandez University)
- Autor: Pedro Gamboa (Hospital de Basurto)
- Autor: Rosa Muñoz (CIBERES)
- Autor: Maria Rosa Sanchez-Monge Y Laguna de Rins (UPM)
- Autor: Sofia Sirvent (Universidad Complutense)
- Autor: Maria J Torres (Fundacio¿n IMABIS-Carlos Haya Hospital)
- Autor: Susana Varela-Losada (Complexo Hospitalario, Ourense)
- Autor: Rosalia Rodriguez (Universidad Complutense)
- Autor: Victor Parro (INTA-CSIC)
- Autor: Miguel Blanca (Fundacio¿n IMABIS-Carlos Haya Hospital)
- Autor: Gabriel Salcedo (UPM)
- Autor: Araceli Diaz Perales (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
- Creador: Grupo de Investigación: Biotecnología de Proteínas Vegetales
- Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
- Departamento: Biotecnología
S2i 2023 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)