Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Año:2012
Áreas de investigación
  • Biología molecular, celular y genética
Datos
Descripción
The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
Internacional
Si
JCR del ISI
Si
Título de la revista
Plos One
ISSN
1932-6203
Factor de impacto JCR
4,092
Información de impacto
Volumen
7
DOI
10.1371/journal.pone.0050799
Número de revista
12
Desde la página
1
Hasta la página
10
Mes
DICIEMBRE
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Aranzazu Palacín Gómez (UPM)
  • Autor: Cristina Gomez Casado (UPM)
  • Autor: Luis A Rivas (INTA-CSIC)
  • Autor: Jacobo Aguirre (Instituto de Investigacio¿n Sanitaria Princesa)
  • Autor: Leticia Tordesillas Villuendas (UPM)
  • Autor: Joan Bartra (CIBERES)
  • Autor: Carlos Blanco (Instituto de Investigacio¿n Sanitaria Princesa)
  • Autor: Teresa Carrillo (Hospital Universitario de Gran Canaria Dr. Negrin,)
  • Autor: Javier Cuesta Herranz (Fundacion Jimenez Diaz,)
  • Autor: Consolación de Frutos (Instituto de Investigacio¿n Sanitaria Princesa)
  • Autor: Genoveva Garc¿a Allvarez-Eire (Complexo Hospitalario, Ourense)
  • Autor: Francisco J Fernandez (General University Hospital, Miguel Hernandez University)
  • Autor: Pedro Gamboa (Hospital de Basurto)
  • Autor: Rosa Muñoz (CIBERES)
  • Autor: Maria Rosa Sanchez-Monge Y Laguna de Rins (UPM)
  • Autor: Sofia Sirvent (Universidad Complutense)
  • Autor: Maria J Torres (Fundacio¿n IMABIS-Carlos Haya Hospital)
  • Autor: Susana Varela-Losada (Complexo Hospitalario, Ourense)
  • Autor: Rosalia Rodriguez (Universidad Complutense)
  • Autor: Victor Parro (INTA-CSIC)
  • Autor: Miguel Blanca (Fundacio¿n IMABIS-Carlos Haya Hospital)
  • Autor: Gabriel Salcedo (UPM)
  • Autor: Araceli Diaz Perales (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología de Proteínas Vegetales
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Biotecnología
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