Memorias de investigación
Research Publications in journals:
Artificial Pancreas Using a Personalized Rule-Based Controller Achieves Overnight Normoglycemia in Patients with Type 1 Diabetes
Year:2013
Research Areas
  • Biomedicine,
  • Electronic technology and of the communications
Information
Abstract
Objective: This study assessed the efficacy of a closed-loop (CL) system consisting of a predictive rule-based algorithm (pRBA) on achieving nocturnal and postprandial normoglycemia in patients with type 1 diabetes mellitus (T1DM). The algorithm is personalized for each patient?s data using two different strategies to control nocturnal and postprandial periods. Research Design and Methods: We performed a randomized crossover clinical study in which 10 T1DM patients treated with continuous subcutaneous insulin infusion (CSII) spent two nonconsecutive nights in the research facility: one with their usual CSII pattern (open-loop [OL]) and one controlled by the pRBA (CL). The CL period lasted from 10 p.m. to 10 a.m., including overnight control, and control of breakfast. Venous samples for blood glucose (BG) measurement were collected every 20 min. Results: Time spent in normoglycemia (BG, 3.9?8.0 mmol/L) during the nocturnal period (12 a.m.?8 a.m.), expressed as median (interquartile range), increased from 66.6% (8.3?75%) with OL to 95.8% (73?100%) using the CL algorithm (P < 0.05). Median time in hypoglycemia (BG, <3.9 mmol/L) was reduced from 4.2% (0?21%) in the OL night to 0.0% (0.0?0.0%) in the CL night (P < 0.05). Nine hypoglycemic events ( <3.9 mmol/L) were recorded with OL compared with one using CL. The postprandial glycemic excursion was not lower when the CL system was used in comparison with conventional preprandial bolus: time in target (3.9?10.0 mmol/L) 58.3% (29.1?87.5%) versus 50.0% (50?100%). Conclusions: A highly precise personalized pRBA obtains nocturnal normoglycemia, without significant hypoglycemia, in T1DM patients. There appears to be no clear benefit of CL over prandial bolus on the postprandial glycemia.
International
Si
JCR
Si
Title
Diabetes Technology & Therapeutics
ISBN
1520-9156
Impact factor JCR
2,205
Impact info
Volume
Journal number
From page
ONLINE
To page
ONLINE
Month
OCTUBRE
Ranking
Participants
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB