Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
The Impact of Computer Science in Molecular Medicine: Enabling High-Throughput Research
Año:2013
Áreas de investigación
  • Ciencias de la computación y tecnología informática
Datos
Descripción
The Human Genome Project and the explosion of high-throughput data have transformed the areas of molecular and personalized medicine, which are producing a wide range of studies and experimental results and providing new insights for developing medical applications. Research in many interdisciplinary fields is resulting in data repositories and computational tools that support a wide diversity of tasks: genome sequencing, genome-wide association studies, analysis of genotype-phenotype interactions, drug toxicity and side effects assessment, prediction of protein interactions and diseases, development of computational models, biomarker discovery, and many others. The authors of the present paper have developed several inventories covering tools, initiatives and studies in different computational fields related to molecular medicine: medical informatics, bioinformatics, clinical informatics and nanoinformatics. With these inventories, created by mining the scientific literature, we have carried out several reviews of these fields, providing researchers with a useful framework to locate, discover, search and integrate resources. In this paper we present an analysis of the state-of-the-art as it relates to computational resources for molecular medicine, based on results compiled in our inventories, as well as results extracted from a systematic review of the literature and other scientific media. The present review is based on the impact of their related publications and the available data and software resources for molecular medicine. It aims to provide information that can be useful to support ongoing research and work to improve diagnostics and therapeutics based on molecular-level insights.
Internacional
Si
JCR del ISI
Si
Título de la revista
CURRENT TOPICS IN MEDICINAL CHEMISTRY
ISSN
1568-0266
Factor de impacto JCR
4,174
Información de impacto
Volumen
13
DOI
10.2174/1568026611313050002
Número de revista
5
Desde la página
526
Hasta la página
575
Mes
SIN MES
Ranking
0
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Diana De la Iglesia Jimenez (UPM)
  • Autor: Miguel Garcia Remesal (UPM)
  • Autor: Guillermo De la Calle Velasco (UPM)
  • Autor: Casimir A Kulikowski (Rutgers)
  • Autor: Ferran Sanz (Biomedical Informatics Research Group, Municipal Institute of Medical Research-IMIM)
  • Autor: Victor Manuel Maojo Garcia (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Informática Biomédica (GIB)
  • Departamento: Inteligencia Artificial
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