Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Predicting dementia development in Parkinson's disease using Bayesian network classifiers
Año:2013
Áreas de investigación
  • Inteligencia artificial
Datos
Descripción
Parkinson's disease (PD) has broadly been associated with mild cognitive impairment (PDMCI) and dementia (PDD). Researchers have studied surrogate, neuroanatomic biomarkers provided by magnetic resonance imaging (MRI) that may help in the early diagnosis of this condition. In this article, four classification models (naïve Bayes, multivariate filter-based naïve Bayes, filter selective naïve Bayes and support vector machines, SVM) have been applied to evaluate their capacity to discriminate between cognitively intact patients with Parkinson's disease (PDCI), PDMCI and PDD. For this purpose, the MRI studies of 45 subjects (16 PDCI, 15 PDMCI and 14 PDD) were acquired and post-processed with Freesurfer, obtaining 112 variables (volumes of subcortical structures and thickness of cortical parcels) per subject. A multivariate filter-based naïve Bayes model was found to be the best classifier, having the highest cross-validated sensitivity, specificity and accuracy. Additionally, the most relevant variables related to dementia in PD, as predicted by our classifiers, were cerebral white matter, and volumes of the lateral ventricles and hippocampi.
Internacional
Si
JCR del ISI
Si
Título de la revista
Psychiatry Research: NeuroImaging
ISSN
0925-4927
Factor de impacto JCR
2,456
Información de impacto
Volumen
213
DOI
Número de revista
2
Desde la página
92
Hasta la página
98
Mes
SIN MES
Ranking
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Participantes
  • Autor: D.A. Morales
  • Autor: Y. Vives-Gilabert
  • Autor: B. Gómez-Ansón
  • Autor: E. Bengoetxea
  • Autor: P. Larrañaga
  • Autor: Maria Concepcion Bielza Lozoya (UPM)
  • Autor: J. Pagonabarraga
  • Autor: J. Kulisevsky
  • Autor: I. Corcuera-Solano
  • Autor: M. Delfino
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Inteligencia Artificial
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