Memorias de investigación
Artículos en revistas:
Emergence of Small-World Anatomical Networks in Self-Organizing Clustered Neuronal Cultures
Año:2014
Áreas de investigación
  • Física química y matemáticas,
  • Ciencias naturales y ciencias de la salud,
  • Ingenierías
Datos
Descripción
In vitro primary cultures of dissociated invertebrate neurons from locust ganglia are used to experimentally investigate the morphological evolution of assemblies of living neurons, as they self-organize from collections of separated cells into elaborated, clustered, networks. At all the different stages of the culture's development, identification of neurons' and neurites' location by means of a dedicated software allows to ultimately extract an adjacency matrix from each image of the culture. In turn, a systematic statistical analysis of a group of topological observables grants us the possibility of quantifying and tracking the progression of the main network's characteristics during the self-organization process of the culture. Our results point to the existence of a particular state corresponding to a small-world network configuration, in which several relevant graph's micro- and meso-scale properties emerge. Finally, we identify the main physical processes ruling the culture's morphological transformations, and embed them into a simplified growth model qualitatively reproducing the overall set of experimental observations.
Internacional
Si
JCR del ISI
Si
Título de la revista
Plos One
ISSN
1932-6203
Factor de impacto JCR
3,73
Información de impacto
Datos JCR del año 2012
Volumen
DOI
Número de revista
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1
Hasta la página
8
Mes
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Participantes
  • Autor: Daniel De Santos Sierra UPM
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Centro o Instituto I+D+i: Centro de Domótica Integral, CEDINT
  • Departamento: Matemática Aplicada a Las Tecnologías de la Información y Las Comunicaciones