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Descripción
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| Introduction: Exercise increases several inflammation markers, especially Interleukin-6 (IL-6) and C-reactive protein (CRP). Some studies have linked the exercise-induced production of IL-6 and CRP with the observed elevation of hepcidin after exercise. Therefore, these responses are proposed to explain iron deficiency among athletes. The aim of this study was to elucidate the effect of vitamin C and E supplementation in the inflammatory response after exercise in healthy humans. Methods: Ten well-trained male students of Sport Sciences (26.9 6 6.7 years, 69.3 6 8.8 kg and 176.6 6 7.5 cm) participated in this study. Subjects received an oral supplementation with a combination of ascorbic acid (500 mg/d) and RRR-a-tocopherol (400 IU/d). Before and after 28 days of supplementation the participants performed 1.5 hours running trial at the speed corresponding to the 75% of the maximum oxygen consumption (V_ O2max) previously determined. Venous blood samples were obtained pre-trial (BS), immediately posttrial (0 h), and at 3, 6, and 10 hours post-trial. Results: IL-6 (BS: 0.358 6 0.251 vs. 0.365 6 0.311 pg/ml; 0 hours: 16.115 6 7.879 vs. 15.685 6 6.510 pg/ml; 3 hours: 8.553 6 6.150 vs. 4.748 6 3.201 pg/ml; 6 hours: 8.381 6 11.989 vs. 3.568 6 2.834 pg/ml; 10 hours: 9.062 6 15.519 vs. 3.241 6 3.641 pg/ml, before and after supplementation respectively) and CRP (BS: 0.036 6 0.019 vs. 0.048 6 0.037 mg/dl; 0 h: 0.036 6 0.018 vs. 0.049 6 0.035 mg/dl; 3 hours: 0.035 6 0.018 vs. 0.0486 0.034 mg/dl; 6 hours: 0.057 6 0.036 vs. 0.074 6 0.050 mg/dl; 10 hours: 0.125 6 0.086 vs. 0.125 6 0.095 mg/dl, before and after supplementation respectively). Levels were not significantly different after supplementation, however, both responses were significantly higherafter exercise regarding to baseline levels. Discussion: Fischer et al. reported that vitamins C and E inhibit the release of IL-6 from contracting human skeletal muscle. By contrast, there were not IL-6 and CRP inhibition after supplementation in our study. Although the response of IL-6 tended to be lower after supplementation, this reduction was not significant. Nevertheless, there was an increase of inflammatory response after exercise regarding to baseline levels such as Peeling et al. showed in their study. More studies are necessary to understand these complex mechanisms. | |
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Internacional
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Si |
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Nombre congreso
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IV NSCA INTERNATIONAL CONFERENCE |
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Tipo de participación
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960 |
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Lugar del congreso
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Murcia, España |
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Revisores
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Si |
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ISBN o ISSN
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1064-8011 |
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DOI
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Fecha inicio congreso
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26/06/2014 |
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Fecha fin congreso
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28/06/2014 |
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Desde la página
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2 |
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Hasta la página
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2 |
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Título de las actas
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The Journal of Strength and Conditioning Research (JSCR) |