Observatorio de I+D+i UPM

Descripción
Alt a 1 is a protein found in Alternaria alternata spores related to virulence and pathogenicity and considered to be responsible for chronic asthma in children. We found that spores of Alternaria inoculated on the outer surface of kiwifruits did not develop hyphae. Nevertheless, the expression of Alt a 1 gene was upregulated, and the protein was detected in the pulp where it co-localized with kiwi PR5. Pull-down assays demonstrated experimentally that the two proteins interact in such a way that Alt a 1 inhibits the enzymatic activity of PR5. These results are relevant not only for plant defense, but also for human health as patients with chronic asthma could suffer from an allergic reaction when they eat fruit contaminated with Alternaria.
Internacional	Si
JCR del ISI	Si
Título de la revista	Febs Letters
ISSN	0014-5793
Factor de impacto JCR	3,341
Información de impacto
Volumen
DOI
Número de revista
Desde la página	1501
Hasta la página	1508
Mes	SIN MES
Ranking

Esta actividad pertenece a memorias de investigación

• Autor: Cristina Gomez Casado (UPM)
• Autor: Maria Garrido Arandia (UPM)
• Autor: Amaya Murua Garcia (UPM)
• Autor: Pablo Gonzalez-Melendi De Leon (UPM)
• Autor: Rosa Sánchez-Monge
• Autor: Domingo Barber
• Autor: Luis Fernandez Pacios (UPM)
• Autor: Araceli Diaz Perales (UPM)

• Creador: Grupo de Investigación: Interacciones moleculares planta-insecto.
• Grupo de Investigación: Biotecnología Vegetal
• Departamento: Sistemas y Recursos Naturales
• Departamento: Biotecnología - Biología Vegetal