Memorias de investigación
Research Publications in journals:
Functional Hubs in Mild Cognitive Impairment
Year:2015

Research Areas
  • Natural sciences and health sciences

Information
Abstract
We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures.
International
Si
JCR
Si
Title
International Journal of Bifurcation and Chaos
ISBN
0218-1274
Impact factor JCR
1,078
Impact info
Volume
25
10.1142/S0218127415500340
Journal number
3
From page
1550034-1
To page
1550034-10
Month
MARZO
Ranking
Participants
  • Autor: Adrian Navas Santo-Tomas UPM
  • Autor: David Papo . UPM
  • Autor: Stefano Boccaletti . UPM
  • Autor: Francisco del-Pozo UPM
  • Autor: Ricardo Bajo Breton UPM
  • Autor: Fernando Maestu Unturbe UPM
  • Autor: Johann Heinz Martínez UPM
  • Autor: Pablo Aguilar Gil UPM
  • Autor: Irene Sendiá-Nadal URJC
  • Autor: Javier Martín Buldú UPM

Research Group, Departaments and Institutes related
  • Creador: Departamento: Tecnología Fotónica y Bioingeniería