Observatorio de I+D+i UPM

Descripción
We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures.
Internacional	Si
JCR del ISI	Si
Título de la revista	International Journal of Bifurcation and Chaos
ISSN	0218-1274
Factor de impacto JCR	1,078
Información de impacto
Volumen	25
DOI	10.1142/S0218127415500340
Número de revista	3
Desde la página	1550034-1
Hasta la página	1550034-10
Mes	MARZO
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• Creador: Departamento: Tecnología Fotónica y Bioingeniería