Memorias de investigación
Artículos en revistas:
Injection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap after Unilateral Vocal Fold Paralysis
Año:2018
Áreas de investigación
  • Medicina clínica,
  • Bioinstrumentación
Datos
Descripción
Paralysis of one vocal fold leads to glottal gap and vocal fold insufficiency that has significant impact upon a patient's quality of life. Fillers have been tested to perform intracordal injections, but they do not provide perdurable results. Early data suggest that enriching fat grafts with adipose-derived regenerative cells (ADRCs) promote angiogenesis and modulate the immune response, improving graft survival. The aim of this study is to propose ADRC-enriched adipose tissue grafts as effective filler for the paralyzed vocal fold to use it for functional reconstruction of the glottal gap. Method. This is the first phase I-IIA clinical trial (phase I/IIA clinical trial, unicentric, randomized, controlled, and two parallel groups), to evaluate the safety of a new therapy with ADRC-enriched fat grafting (ADRC: group I) for laryngoplasty after unilateral vocal fold paralysis. Control group patients received centrifuged autologous fat (CAF: group II) grafts. Overall mean age is 52.49 ± 16.60 years. Group I (ADRC): 7 patients (3 males and 4 females), 52.28 ± 20.95 year. Group II (CAF): 7 patients (3 males and 4 females), 52.71 ± 12.59 year. Results. VHI-10 test showed that preoperative mean score was 24.21 ± 8.28. Postoperative mean score was 6.71 ± 6.75. Preoperative result in group I was 21.14 ± 3.58 and postoperative result was 3.14 ± 3.53. Preoperative result for group II was 27.29 ± 10.66. Postoperative score in group II was 10.29 ± 7.52. Wilcoxon and the Student t-tests showed that the patient?s self-perception of posttreatment improvement is larger when ADRCs are used. Comparing pre- and posttreatment voice quality analysis, group I showed a p = 0 053. Group II showed a p = 0 007. There would be no significant differentiation between pre- and posttreatment results. This is true for group II and limited for group I. Conclusions. This prospective trial demonstrates the safety and efficacy of the treatment of glottal gap defects utilizing ADRC-enriched fat grafts. This trial is registered with NCT02904824.
Internacional
Si
JCR del ISI
Si
Título de la revista
Stem Cells International
ISSN
1687-966X
Factor de impacto JCR
3,989
Información de impacto
Volumen
DOI
10.1155/2018/8917913
Número de revista
Volume 201
Desde la página
1
Hasta la página
15
Mes
SIN MES
Ranking
Q2 43/97
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: José María Lasso Hospital General Universitario Gregorio Marañón
  • Autor: Daniel Poletti Hospital General Universitario Gregorio Marañón
  • Autor: Bartolomé Scola Hospital General Universitario Gregorio Marañón
  • Autor: Pedro Gomez Vilda UPM
  • Autor: Ana Isabel García Hospital General Universitario Gregorio Marañón
  • Autor: María Eugenia Fernández Hospital General Universitario Gregorio Marañón
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Informática Aplicada al Procesado de Señal e Imagen
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Arquitectura y Tecnología de Sistemas Informáticos