Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Impact of APOE2 allele on lipid profile change after a weight loss program
Año:2018
Áreas de investigación
  • Fisiología,
  • Fisiología de los deportes,
  • Salud
Datos
Descripción
BACKGROUND: apolipoprotein E (ApoE) polymorphism is a genetic determinant of lipid and lipoprotein levels and the risk for coronary heart disease. OBJECTIVE: to evaluate the impact of ApoE2allele in lipid plasma levels and the influence of a healthy hypocaloric diet plus a controlled physical activity on the lipid profile, we performed a study in a cohort of overweight and obese healthy subjects (Body Mass Index (BMI) between 25 and 34.9 kg·m-2). METHODS: one hundred eighty participants (96 women), aged 18-50 years participated in a 22 weeks weight loss intervention based on same dietary treatment and different controlled exercise programs. All subjects followed a hypocaloric diet (25-30% less energy intake than the daily energy expenditure). Blood samples were obtained for lipids measurements at the beginning and end of the study. RESULTS: after intervention, men of the E2 group showed the greatest decreases in low-density lipoprotein (LDL), triglycerides (TG) and total cholesterol (TC) values (p = 0.039; p = 0.001; p = 0.001; respectively). For high-density lipoprotein (HDL), E2 group had significant differences compared with E4 at pre- (p = 0.020) and post-intervention values (p = 0.024). CONCLUSION: our results show great changes in men carrying ApoE2, mainly in TG and TC concentrations after treatment with hypocaloric diet and controlled exercise. Therefore, adding supervised training to nutritional intervention seems to be a good alternative for the reinforcement of the effect of the treatment.
Internacional
Si
JCR del ISI
Si
Título de la revista
Nutricion Hospitalaria
ISSN
0212-1611
Factor de impacto JCR
0,747
Información de impacto
Volumen
35
DOI
10.20960/nh.1278
Número de revista
2
Desde la página
305
Hasta la página
311
Mes
SIN MES
Ranking
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Participantes
  • Autor: Rocio Cupeiro Coto (UPM)
  • Autor: Fco. Javier Calderon Montero (UPM)
  • Autor: Ana Belen Peinado Lozano (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Investigación del Laboratorio de Fisiología del Esfuerzo.
  • Departamento: Salud y Rendimiento Humano
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