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Descripción
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| Titanium and its alloys are among the most-frequently used biomaterials for the replacement of hard tissue. This choice is due to their good corrosion resistance, superior mechanical properties and excellent biocompatibility. The feature that separates titanium and titanium alloys from the rest of the metallic biomaterials, is their elastic modulus which is lower than that of the rest of the metallic biomaterials and closer to the elastic modulus of bone. These properties make titanium alloys the ultimate choice for fabrication of biomaterials for hard tissue replacement, particularly for load-bearing applications. However, a drawback in using titanium as bone implant is that it lacks the ability to establish a direct contact with the adjacent bone. More often, the implant is surrounded by a capsule of fibrous tissue. The specialized tissue is able to form on top of the fibrous tissue layer, but the fibrous tissue acts as a mechanically weak link between the implant and the newly formed bone. The presence of this fibrous tissue layer might cause infections or loosening of the implant and lead to the need for revision surgery. In this regard, development of biomaterials capable of establishing a close integration with bone tissue is of outmost importance. One strategy to address this problem is to modify the surface of the material by covalently binding proper biomolecules capable of promoting the activity of specialized bone cells on the surface, while preserving the excellent bulk properties of the material. | |
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Internacional
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ISBN
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Tipo de Tesis
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Doctoral |
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Calificación
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Sobresaliente cum laude |
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Fecha
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18/06/2018 |