Memorias de investigación
Communications at congresses:
Quantitative analysis of early-phase 18F-flutemetamol PET brain images
Year:2019
Research Areas
  • Electronic technology and of the communications
Information
Abstract
PET imaging techniques can be used to visualise the two major biomarkers of Alzheimer?s disease (AD). A series of radiotracers bind to amyloid-beta (A?) plaques in the brain while cerebral metabolism is assessed on 18F-fluorodeoxyglucose (FDG) PET images. It is demonstrated that acquiring a PET image up to 10 minutes after the injection of an A?-binding tracer yields images that resemble PET images acquired with FDG. Therefore, these early-phase PET-amyloid images are suggested to be a surrogate to PET-FDG images and offer information about the cerebral perfusion, which is closely linked to the cerebral metabolism. In this work, early-phase PET images acquired with 18F-flutemetamol (FMM) are analysed and the correlation with FDG images is quantitatively assessed. Moreover, the results are compared to studies that used two different A?- binding tracers, namely 18F-florbetapir (FBP) and 18Fflorbetaben (FBB). The Pearson?s correlation coefficient (r) is used to analyse how the standard uptake value ratios (SUVR) of different regions of interest of early-phase FMM and FDG images are related. An average correlation (± standard deviation) of r = 0.76 ± 0.07 is obtained. ROI-based analysis showed that the highest correlation between both images is present in the right temporal lobe (r = 0.85). These values are comparable to the two selected studies that are based on early-phase FBP and FBB images. Therefore, the results suggest that early-phase PET-FMM acquisitions offer similar information to PET-FDG images.
International
No
Congress
XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB2019)
960
Place
Santander, España
Reviewers
Si
ISBN/ISSN
978-84-09-16707-4
Start Date
27/11/2019
End Date
29/11/2019
From page
183
To page
186
Libro de Actas. XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB2019)
Participants
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB