Observatorio de I+D+i UPM

Memorias de investigación
Ponencias en congresos:
Quantitative analysis of early-phase 18F-flutemetamol PET brain images
Áreas de investigación
  • Tecnología electrónica y de las comunicaciones
PET imaging techniques can be used to visualise the two major biomarkers of Alzheimer?s disease (AD). A series of radiotracers bind to amyloid-beta (A?) plaques in the brain while cerebral metabolism is assessed on 18F-fluorodeoxyglucose (FDG) PET images. It is demonstrated that acquiring a PET image up to 10 minutes after the injection of an A?-binding tracer yields images that resemble PET images acquired with FDG. Therefore, these early-phase PET-amyloid images are suggested to be a surrogate to PET-FDG images and offer information about the cerebral perfusion, which is closely linked to the cerebral metabolism. In this work, early-phase PET images acquired with 18F-flutemetamol (FMM) are analysed and the correlation with FDG images is quantitatively assessed. Moreover, the results are compared to studies that used two different A?- binding tracers, namely 18F-florbetapir (FBP) and 18Fflorbetaben (FBB). The Pearson?s correlation coefficient (r) is used to analyse how the standard uptake value ratios (SUVR) of different regions of interest of early-phase FMM and FDG images are related. An average correlation (± standard deviation) of r = 0.76 ± 0.07 is obtained. ROI-based analysis showed that the highest correlation between both images is present in the right temporal lobe (r = 0.85). These values are comparable to the two selected studies that are based on early-phase FBP and FBB images. Therefore, the results suggest that early-phase PET-FMM acquisitions offer similar information to PET-FDG images.
Nombre congreso
XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB2019)
Tipo de participación
Lugar del congreso
Santander, España
Fecha inicio congreso
Fecha fin congreso
Desde la página
Hasta la página
Título de las actas
Libro de Actas. XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB2019)
Esta actividad pertenece a memorias de investigación
  • Autor: Alexander Peter Seiffert (UPM)
  • Autor: Enrique Javier Gomez Aguilera (UPM)
  • Autor: Patricia Sanchez Gonzalez (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2021 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)